CAS: 1591-30-6; [1,1'-Biphenyl]-4,4'-Dicarbonitrile

相似化合物

787-70-2 66-98-8 5728-46-1

上下游产品

p,p'-diaminobiphenyl 4,4'-dinitrobiphenyl potassium cyanide sodium cyanide 4,4'-diacetylbiphenyl 4,4'-bis(4,5-dihydro-1H-imidazol-2-yl)biphenyl 4,4'-dibenzoyl-1,1'-biphenyl 4,4'-Bis-phenylacetyl-biphenyl

📜4,4'-二甲基联苯置于盐酸羟胺,2,4,6-Triphenylpyrylium Tetrafluoroborate,氧气,溴化铵体系中,用 乙腈 用作溶剂,40.0 °C,100.0 Kpa 条件下,反应 48.0H,以40%的收率获得4,4'-联苯甲腈
参考文献:可见光促进 C(Sp3)−h 键无金属合成(杂)芳香腈**
标题:可见光促进 C(Sp3)−h 键无金属合成(杂)芳香腈**
摘要:C(Sp 3 )−h 键的无金属活化生成增值产品在有机合成中至关重要.我们报道了使用市售有机染料 2,4,6-三苯基吡喃鎓四氟硼酸盐 (Tpp) 通过光催化过程将甲基芳烃转化为相应的芳基腈.应用这种方法,在不含金属和氰化物的条件下,可以以非常好到优异的收率合成多种氰基苯.我们通过 50 多个示例证明了该方法的范围,包括药物分子(塞来昔布)的后期功能化和l-薄荷醇,氨基酸和胆固醇衍生物等复杂结构.此外,所提出的合成方案适用于克级反应.除了甲基芳烃之外,还展示了醛,醇和肟氰化的选定示例.使用时间分辨发光猝灭研究,控制实验,核磁共振波谱以及动力学研究进行了详细的机理研究,所有这些都支持了所提出的催化循环.
Doi:10.1002/anie.202011815

专利信息

专利号:WO-2010146391-A1
优先权日:2009-06-15
标题:Regioselective synthesis of letrozole
发明人：GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
权利人:GENERICS UK LTD; MYLAN INDIA PRIVATE LTD; GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
摘要:The present invention relates to an improved process for the preparation of letrozole (I) and its pharmaceutically acceptable salts, to compositions comprising letrozole or a pharmaceutically acceptable salt thereof, and to uses of such compositions. In particular it relates to a process and to novel intermediates for preparing letrozole and its salts substantially free from regioisomeric impurities.

专利号:US-4031106-A
优先权日:1973-12-19
标题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
发明人：DELPESCO THOMAS WAYNE
权利人:DU PONT
摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150 DEG C. to about 500 DEG C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant containing an oxide of lanthanum, samarium, holmium, europium, erbium, yttrium, praseodymium, neodymium, terbium, ytterbium, dysprosium or a mixture of any of them.

专利号:US-4001260-A
优先权日:1973-12-19
标 题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
发明人：DEL PESCO THOMAS W
权利人:DU PONT
摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150° C. to about 500° C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant which has been treated with ammonia prior to introduction of the cataloreactant to the amination reactants.

专利号:CN-115634708-B
优先权日:2022-11-14
标题 :Synthesis method and application of nitrogen-doped porous carbon-nickel supported catalyst

专利号:CN-115634708-A
优先权日:2022-11-14
标 题 :Synthesis method and application of nitrogen-doped porous carbon-nickel supported catalyst