CAS: 153259-31-5; 2-(Chloromethyl)-4-(3-Methoxypropoxy)-3-Methylpyridine Hydrochloride

相似化合物

675198-19-3 86604-74-2 117977-20-5

2-羟甲基-4-甲氧基丙氧基-3-甲基吡啶置于氯化亚砜体系中,用 乙酸乙酯 用作溶剂,化学反应 3.0H,以95.7%的收率获得2-氯甲基-3-甲基-4-(3-甲氧丙氧基)吡啶盐酸盐
参考文献:一种雷贝拉唑氯化物及其中间体的制备方法
标题:一种雷贝拉唑氯化物及其中间体的制备方法
摘要:现有方法在由式iv合成式iii时采用乙酸酐进行反应,反应温度高,时间长,且反应过程中会产生大量异构体副产物,导致产物纯度偏低.在由式ii化合物游离碱合成式i化合物时,采用卤代烷烃用作溶剂,氯化亚砜为氯代试剂进行反应,后处理需用碱淬灭,水洗萃取,浓缩后再成盐,操作复杂,生产周期长.本发明公开了在制备式iii化合物时添加对甲苯磺酸进行催化,使反应在较低温度下就可以进行,大大降低了副反应,提高了产物的纯度.在制备式i化合物时,以乙酸乙酯做溶剂,随着反应的进行,产物会逐渐析出,反应完全后直接过滤就可以得到产品,后处理简单,产品纯度高,适合工业化生产.

专利信息

专利号:US-7638633-B2
优先权日:2005-02-21
标题 :Process for synthesis of proton pump inhibitors
发明人：PATHI SRINIVAS LAXMINARAYAN; KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA
权利人:CIPLA LTD
摘要:A process for preparation of rabeprazole sodium comprising oxidation of wet or dry rabeprazole sulphide with sodium hypohalite in water or a mixture of water and water miscible solvent using alkali metal hydroxide and catalyst is disclosed herein. The present invention also discloses process for preparation of rabeprazole sulphide.

专利号:US-10111854-B2
优先权日:2014-02-26
标题 :Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents
发明人：CHOW LARRY MING-CHEUNG; Chan Tak Hang William; CHAN KIN-FAI; WONG IRIS LAI KING; KAN WING-YIU
权利人:UNIV HONG KONG POLYTECHNIC
摘要:The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

专利号:US-2008161579-A1
优先权日:2005-02-21
标题 :Process for Synthesis of Proton Pump Inhibitors

专利号:CA-2606799-C
优先权日:2005-02-21
标题 :Process for synthesis of proton pump inhibitors

专利号:AU-2006242782-B2
优先权日:2005-02-21
标题 :New process for synthesis of proton pump inhibitors

专利号:AU-2006242782-A1
优先权日:2005-02-21
标题 :New process for synthesis of proton pump inhibitors