专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-7109220-B2 优先权日:2003-11-19 标 题:Amino substituted pyridinyl methanone compounds useful in treating kinase disorders 发明人:LIN RONGHUI; WETTER STEVEN K; LU YANHUA; CONNOLLY PETER J; EMANUEL STUART; GRUNINGER ROBERT H; MIDDLETON STEVEN A 权利人:JANSSEN PHARMACEUTICA NV 摘要:The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the compounds and/or pharmaceutical compositions to treat such disorders.
专利号:CN-1683378-A 优先权日:2004-04-13 标 题:Synthesis and preparation of nickel-chelidonamic acid film with fluorescent property
专利号:EP-1626982-B1 优先权日:2003-05-23 标 题:Metal chelate complexes immobilized on solid supports for peptide preparation 发明人:RYBKA ANDREAS; FRANK HANS-GEORG; BRACHT FRANZ-PETER; HABERL UDO 权利人:APLAGEN GMBH 摘要:Use of an activated solid phase and an anchoring part which is attached to a peptide for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase. nFurthermore provided is a process for competitively detachment of said anchoring part, for purification and refolding of said peptides. Provided are peptides with an anchoring part for coordinative and reversible attachment of said peptides to an activated solid phase.
专利号:CN-111760594-A 优先权日:2020-07-30 标 题:A kind of vanadium pyridine/TS-1 catalyst for preparing 2,5-dichlorophenol by catalytic oxidation and its synthesis method and application
专利号:CN-111760594-B 优先权日:2020-07-30 标 题 :A kind of vanadium pyridine/TS-1 catalyst for preparing 2,5-dichlorophenol by catalytic oxidation and its synthesis method and application
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合成参考文献
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