CAS: 1365267-27-1; (R)-6-Amino-5-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-N-(4-(4-Methylpiperazine-1-Carbonyl)Phenyl)Pyridazine-3-Carboxamide

上下游产品

6-[bis(Tert-Butoxycarbonyl)Amino]-5-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy]Pyridazine-3-Carboxylic Acid 1370651-36-7
6-[双[(1,1-二甲基乙氧基)羰基]氨基]-5-[(1R)-1- (2,6-二氯-3-氟苯基)乙氧基]-3-吡嗪羧酸乙酯 Ethyl 6-[bis[(2-Methylpropan-2-yl)Oxycarbonyl]Amino]-5-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy]Pyridazine-3-Carboxylate 1370651-34-5
(R)-6-Chloro-4-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridazin-3-Amine 1370651-29-8
(R)-6-Chloro-4-[1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy]-3-[bis(Boc)Amino]Pyridazine 1370651-32-3

📜6-[双[(1,1-二甲基乙氧基)羰基]氨基]-5-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-3-吡嗪羧酸乙酯置于水,N,N-二异丙基乙胺,Methanaminium,N-[(Dimethylamino)(3H-1,2,3-Triazolo[4,5-B]Pyridin-3-Yloxy)Methylene]-N-Methyl-,Hexafluorophosphate(1-),三氟乙酸,Lithium Hydroxide体系中,用 四氢呋喃,二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 3.0H,反应生成恩沙替尼
参考文献: Substituted Pyridazine Carboxamide Compounds[fr] Composés Substitués De Pyridazine Carboxamide
标题: Substituted Pyridazine Carboxamide Compounds[fr] Composés Substitués De Pyridazine Carboxamide

专利信息

专利号:WO-2011148392-A1
优先权日:2010-05-28
标题 :Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
权利人:MSN LAB LTD; SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
摘要:The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.

专利号:WO-2011161690-A1
优先权日:2010-06-23
标题:Processes for the preparation of (+)-n,n-dimethyl-2-[1-(naphthalenyloxy) ethyl] benzene methanamine and intermediates thereof
发明人：MOHAN RAO DODDA; KRISHNA REDDY PINGILI; JITHENDER AADEPU; VENUGOPAL BINGI
权利人:SYMED LABS LTD; MOHAN RAO DODDA; KRISHNA REDDY PINGILI; JITHENDER AADEPU; VENUGOPAL BINGI
摘要:The present invention relates to processes for the preparation of S(+)-N,N-dimethyl-2-[1-(naphthalenyloxy)ethyl]benzene methanamine and intermediates thereof. More particularly the present invention relates to preparation of the compound 3(S)-(+)-N,N-dimethylamino-3-phenyl propanol useful as intermediate in the synthesis of pharmaceutically active compounds.

专利号:US-9273030-B2
优先权日:2012-04-02
标题 :Process for the preparation of benzimidazole derivatives and salts thereof
发明人：THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; RAGHURAM SURAPARAJU
权利人:MSN LAB PRIVATE LTD
摘要:Provided are novel salts of benzimidazole derivatives, preferably salts of benzimidazole derivatives which are useful intermediates in the synthesis of pure 1-methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide and its salts.

专利号:US-5521263-A
优先权日:1994-10-18
标 题:Catalysts and synthesis of high molecular weight amorphous polyolefins and recovery thereof
发明人：SEEGER HORST K; HOLLIDAY ROBERT E
权利人:EASTMAN CHEM CO
摘要:A process for the production of amorphous polyolefins is disclosed. The process entails contacting the olefin monomer, in an unreactive hydrocarbon solvent, with a catalyst in a recirculated, stirred reactor thereby producing amorphous polyolefin. The reactor is capable of recirculating contents that are very viscous.

专利号:US-2020095195-A1
优先权日:2018-09-26
标 题:Synthesis of novel intermediate(s) for preparing rivastigmine

专利号:EP-4217339-A1
优先权日:2020-09-26
标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof