专利号:WO-2024189634-A1 优先权日:2023-03-13 标 题 :Highly atom economical process for synthesis of novel co-initiator for photo-induced radical polymerisation 发明人:KAPAT DR AJOY; AHMAD ASRAR; MITTAL GARVISHA 权利人:SHIV NADAR INSTITUTION OF EMINENCE DEEMED TO BE UNIV 摘要:The present invention relates to a base catalyzed sequential conjugate addition reaction for the synthesis of a novel and efficient co-initiator for Photo Induced Radical Polymerization. The process comprises synthesis of new co-initiator having 6,5 and 6,6-bicyclic scaffolds as central core. The process comprises reacting thiocarboxylic acid, catechol, thiocatechol, benzodithiol, benzothiocatechol and binol with ketone substrates at room temperature with a base and a solvent to yield the novel co-initiator compound of Formula 3, Formula 5, Formula C and Formula Z.
专利号:US-2006128930-A1 优先权日:2004-12-03 标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants 发明人:DHAWAN ASHISH; CHOLLI ASHOK L 权利人:DHAWAN ASHISH; CHOLLI ASHOK L 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:US-7678877-B2 优先权日:2004-12-03 标题 :Process for the synthesis of polyalkylphenol antioxidants 发明人:YANG SUIZHOU; CHOLLI ASHOK L 权利人:POLNOX CORP 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:WO-9845231-A1 优先权日:1997-04-09 标题:Supports for solid phase synthesis 发明人:SHAO HUI; CASTELHANO ARLINDO L 权利人:CADUS PHARMACEUTICAL CORP 摘要:Supports for solid-phase synthesis are disclosed. The supports include a phenol or thiophenol linker moiety. A substrate compound can be immobilized to the support through the linker moiety. The supports are suitable for combinatorial synthesis, including synthesis of combinatorial libraries.
专利号:US-8012901-B1 优先权日:2006-08-30 标 题 :Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers 发明人:ORTIZ-MARCIALES MARGARITA; HUANG KUN; STEPANENKO VIATCHESLAV; DE JESUS MELVIN; CORREA WILDELIZ 权利人:ORTIZ-MARCIALES MARGARITA; HUANG KUN; STEPANENKO VIATCHESLAV; DE JESUS MELVIN; CORREA WILDELIZ 摘要:A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues using 10% of a novel spiroborate ester as chirality transfer agent is presented. A variety of mexiletine analogues were prepared with excellent enantioselectivities (91-97% ee) in good yield from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel β-amino ethers containing thiophenyl and pyridyl fragments.
专利号:WO-2024261784-A1 优先权日:2023-06-22 标题:Organometallic complexes and compounds of mercaptophenols and curcumin for therapeutic applications 发明人:GHOSH SUPRATIM 权利人:GHOSH SUPRATIM 摘要:The present disclosure discloses a group of organometallic complexes and compounds of curcumin and mercaptophenols with various metals having therapeutic potential and processes for the preparation thereof for the treatment of cancer and other diseases The present disclosure further discloses chemical strategy for synthesis of water soluble and stable formulations by bonding metal atom (M) or amino (-NH2) group to α-carbon atom, the carbon between two ionizable groups (-C=O / -OH / -SH) of phenolic molecules, curcumin or mercaptophenols for biomedical applications. The present disclosure provides for complexes that comprise bonding of metal (M) atoms either only to sulfur atom or oxygen atom of mercaptophenol molecule. The compounds and complexes are significantly beneficial for cancer therapy and treatment of other diseases, as they can inhibit disease causing cell proliferation and induce host immune system, and also could be administered in a prodrug form, avoiding the formation of toxic molecules.
[参考文献]: Jana Margetínová, Et Al. Speciation Analysis Of Mercury In Sediments, Zoobenthos And River Water Samples By High-Performance Liquid Chromatography Hyphenated To Atomic Fluorescence Spectrometry Following Preconcentration By Solid Phase Extraction. Anal Chim Acta. 2008 May 19;615(2):115-23. [参考文献]: Steven Goossens, Et Al. Zeb2 Drives Immature T-Cell Lymphoblastic Leukaemia Development Via Enhanced Tumour-Initiating Potential And Il-7 Receptor Signalling. Nat Commun. 2015 Jan 7:6:5794.
合成参考文献
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