CAS: 1121-24-0; 2-Hydroxythiophenol

该化合物是一种含有硫磺的芳香化合物,具有氢氧基和硫醇功能组别,这种双功能结构使该化合物能够用作有机合成的多用途中间体,特别是在生产三环化合物,药品和农用化学物时.它的活性硫醇组可以进行外观的凝聚或金属协调,而氢氧基组则具有额外的衍生潜力.该化合物因其在催化,聚合物稳定以及作为协调化学中的悬浮体的作用而受到重视.高纯度可以满足严格的应用要求.适当的处理由于其对氧化和潜在再活动具有敏感性而至关重要.

结构式图片

相似化合物

2889-61-4 40248-84-8 1073-29-6

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ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

    2-碘苯酚置于copper(Ll) Sulfate Pentahydrate,1,2-乙二硫醇,Potassium Hydroxide体系中,用 水,二甲基亚砜 用作溶剂,化学反应 20.0H,以95%的收率获得2-羟基苯硫酚
    参考文献:铜(II)催化由芳基卤化物和1,2-乙二硫醇合成芳基硫醇
    标题:铜(II)催化由芳基卤化物和1,2-乙二硫醇合成芳基硫醇
    摘要:利用铜(II)催化剂和1,2-乙二硫醇开发了一种高效的过渡金属催化的从芳基卤化物单步合成芳基硫醇的方法.关键特征是使用现成的试剂,简单的操作以及相对温和的反应条件.该新协议显示了广泛的底物范围,具有出色的官能团相容性.由芳基卤化物直接以高收率制备各种芳基硫醇.此外,芳基硫醇原位用于合成更高级的分子,例如二芳基硫醚和苯并噻吩.
    Doi:10.1002/adsc.201400941

    海关参考信息

    专利信息


    专利号:WO-2024189634-A1
    优先权日:2023-03-13
    标 题 :Highly atom economical process for synthesis of novel co-initiator for photo-induced radical polymerisation
    发明人:KAPAT DR AJOY; AHMAD ASRAR; MITTAL GARVISHA
    权利人:SHIV NADAR INSTITUTION OF EMINENCE DEEMED TO BE UNIV
    摘要:The present invention relates to a base catalyzed sequential conjugate addition reaction for the synthesis of a novel and efficient co-initiator for Photo Induced Radical Polymerization. The process comprises synthesis of new co-initiator having 6,5 and 6,6-bicyclic scaffolds as central core. The process comprises reacting thiocarboxylic acid, catechol, thiocatechol, benzodithiol, benzothiocatechol and binol with ketone substrates at room temperature with a base and a solvent to yield the novel co-initiator compound of Formula 3, Formula 5, Formula C and Formula Z.

    专利号:US-2006128930-A1
    优先权日:2004-12-03
    标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants
    发明人:DHAWAN ASHISH; CHOLLI ASHOK L
    权利人:DHAWAN ASHISH; CHOLLI ASHOK L
    摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.

    专利号:US-7678877-B2
    优先权日:2004-12-03
    标题 :Process for the synthesis of polyalkylphenol antioxidants
    发明人:YANG SUIZHOU; CHOLLI ASHOK L
    权利人:POLNOX CORP
    摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.

    专利号:WO-9845231-A1
    优先权日:1997-04-09
    标题:Supports for solid phase synthesis
    发明人:SHAO HUI; CASTELHANO ARLINDO L
    权利人:CADUS PHARMACEUTICAL CORP
    摘要:Supports for solid-phase synthesis are disclosed. The supports include a phenol or thiophenol linker moiety. A substrate compound can be immobilized to the support through the linker moiety. The supports are suitable for combinatorial synthesis, including synthesis of combinatorial libraries.

    专利号:US-8012901-B1
    优先权日:2006-08-30
    标 题 :Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers
    发明人:ORTIZ-MARCIALES MARGARITA; HUANG KUN; STEPANENKO VIATCHESLAV; DE JESUS MELVIN; CORREA WILDELIZ
    权利人:ORTIZ-MARCIALES MARGARITA; HUANG KUN; STEPANENKO VIATCHESLAV; DE JESUS MELVIN; CORREA WILDELIZ
    摘要:A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues using 10% of a novel spiroborate ester as chirality transfer agent is presented. A variety of mexiletine analogues were prepared with excellent enantioselectivities (91-97% ee) in good yield from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel β-amino ethers containing thiophenyl and pyridyl fragments.

    专利号:WO-2024261784-A1
    优先权日:2023-06-22
    标题:Organometallic complexes and compounds of mercaptophenols and curcumin for therapeutic applications
    发明人:GHOSH SUPRATIM
    权利人:GHOSH SUPRATIM
    摘要:The present disclosure discloses a group of organometallic complexes and compounds of curcumin and mercaptophenols with various metals having therapeutic potential and processes for the preparation thereof for the treatment of cancer and other diseases The present disclosure further discloses chemical strategy for synthesis of water soluble and stable formulations by bonding metal atom (M) or amino (-NH2) group to α-carbon atom, the carbon between two ionizable groups (-C=O / -OH / -SH) of phenolic molecules, curcumin or mercaptophenols for biomedical applications. The present disclosure provides for complexes that comprise bonding of metal (M) atoms either only to sulfur atom or oxygen atom of mercaptophenol molecule. The compounds and complexes are significantly beneficial for cancer therapy and treatment of other diseases, as they can inhibit disease causing cell proliferation and induce host immune system, and also could be administered in a prodrug form, avoiding the formation of toxic molecules.
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    主要参考文献

    [参考文献]: Jana Margetínová, Et Al. Speciation Analysis Of Mercury In Sediments, Zoobenthos And River Water Samples By High-Performance Liquid Chromatography Hyphenated To Atomic Fluorescence Spectrometry Following Preconcentration By Solid Phase Extraction. Anal Chim Acta. 2008 May 19;615(2):115-23.
    [参考文献]: Steven Goossens, Et Al. Zeb2 Drives Immature T-Cell Lymphoblastic Leukaemia Development Via Enhanced Tumour-Initiating Potential And Il-7 Receptor Signalling. Nat Commun. 2015 Jan 7:6:5794.

    合成参考文献


    摘要:Kantlehner, W., Science of Synthesis Knowledge Updates, (2014) 4, 365.
    摘要:Zimmer, R.; Trawny, D., Science of Synthesis Knowledge Updates, (2013) 4, 202.
    摘要:National Technical Information Service., OTS0537007
    摘要:Hou, W.; Yang, G.; Xu, H., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 188.
    摘要:Hou, W.; Yang, G.; Xu, H., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 191.
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