CAS: 101467-40-7; (R)-7-Methoxy-1-Methyl-1,2,3,4-Tetrahydroisoquinolin-6-Ol
- 英文名称(R)-7-Methoxy-1-Methyl-1,2,3,4-Tetrahydroisoquinolin-6-Ol
- 中文名称(R)-7-甲氧基-1-甲基-1,2,3,4-四氢异喹啉-6-醇
- IUPAC名称(R)-7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol
- 其它别名6-Isoquinolinol,1,2,3,4-tetrahydro-7-methoxy-1-methyl-, (R)-; (+)-Salsoline; (R)-Salsoline; d-Salsoline
- CAS编号101467-40-7
- MFCD编号:MFCD06797999
- FDA UNII编号:9Q83ETU10C
- 分子式:C11H15NO2分子量:193.24
- 产品CID: 27786
- 产品分类有机原料→官能团→醚
相似化合物
79906-89-1 76419-97-1 1452487-96-5物理性质
MSDS等安全信息
上下游产品
7-甲氧基-6-羟基-1-甲基-1,2,3,4-四氢异喹啉 Rac-Salsoline 89-31-6Benzyl (6-Benzyloxy-7-Methoxy-1-Methyl-3,4-Dihydro-1H-Isoquinoline)-2-Carboxylate 350586-92-4
合成工艺路线路线简述
📜2-(3-(苄氧基)-4-甲氧基苯基)乙胺置于palladium On Activated Charcoal 甲酸,氢气,Potassium Carbonate,对甲苯磺酸体系中,用 甲醇,二氯甲烷 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 33.5H,反应生成叉明草素
参考文献:Pinet; Chavant; Averbuch-Pouchot,Journal Of Chemical Research-Part S,2001,# 2,P. 65-67
标题:Pinet; Chavant; Averbuch-Pouchot,Journal Of Chemical Research-Part S,2001,# 2,P. 65-67
海关参考信息
- 2905199090-其他饱和一元醇
2905399099-其他二元醇
2905499000-其他多元醇
2905590090-其他无环醇的卤化、磺化等衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Chebaibi M, Bourhia M, Amrati FE, Slighoua M, Mssillou I, Aboul-Soud MAM, Khalid A, Hassani R, Bousta D, Achour S, Benhida R, Daoud R. Salsoline derivatives, genistein, semisynthetic derivative of kojic acid, and naringenin as inhibitors of A42R profilin-like protein of monkeypox virus: in silico studies. Front Chem. 2024 Sep 10;12:1445606. doi: 10.3389/fchem.2024.1445606.
2: Ibrayev MK, Nurkenov OA, Rakhimberlinova ZB, Takibayeva AT, Palamarchuk IV, Turdybekov DM, Kelmyalene AA, Kulakov IV. Synthesis, Structure and Molecular Docking of New 4,5-Dihydrothiazole Derivatives Based on 3,5-Dimethylpyrazole and Cytisine and Salsoline Alkaloids. Molecules. 2022 Nov 5;27(21):7598. doi: 10.3390/molecules27217598.
3: Borg S, Kvande H, Magnuson E, Sjöqvist B. Salsolinol and salsoline in cerebrospinal lumbar fluid of alcoholic patients. Acta Psychiatr Scand Suppl. 1980;286:171-7. doi: 10.1111/j.1600-0447.1980.tb08064.x. 2(8289):80-1. 183(1):17-24. doi: 10.1016/s0378-4347(00)81393-6. 17(1):134-7. doi: 10.1021/jm00247a027.
合成参考文献
参考文献:10.1046/j.1471-4159.2001.00448.x
摘要:Maruyama W, Akao Y, Youdim MBH, Davis BA, Naoi M. Transfection‐enforced Bcl‐2 overexpression and an anti‐Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde‐3‐phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N‐methyl(R)salsolinol. Journal of Neurochemistry. 2001 Aug 15;78(4):727–35. doi: 10.1046/j.1471-4159.2001.00448.x.
摘要:Naoi M, Maruyama W. N-methyl(R)salsolinol, a dopamine neurotoxin, in Parkinson's disease. Adv Neurol. 1999;80():259–64.
参考文献:10.3143/geriatrics.38.494
摘要:Maruyama W. [Pathogenesis of idiopathic Parkinson's disease]. Nihon Ronen Igakkai Zasshi. 2001 Jul;38(4):494–7. doi: 10.3143/geriatrics.38.494.
参考文献:10.1007/s007020200050
摘要:Naoi M, Maruyama W, Akao Y, Yi H. Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines. J Neural Transm (Vienna). 2002 May;109(5-6):607–21. doi: 10.1007/s007020200050.
参考文献:10.1007/bf03033216
摘要:Gélinas S, Bureau G, Valastro B, Massicotte G, Cicchetti F, Chiasson K, Gagne B, Blanchet J, Martinoli MG. Alpha and beta estradiol protect neuronal but not native PC12 cells from paraquat-induced oxidative stress. Neurotox Res. 2004;6(2):141–8. doi: 10.1007/bf03033216.
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