专利号:US-8901352-B2 优先权日:2011-01-13 标题 :Method for the synthesis of rasagiline 发明人:REIS ÖMER; KOYUNCU HASAN; ESIRINGU ILKER; SAHIN YASEMIN; GULCAN H OZAN 权利人:REIS ÖMER; KOYUNCU HASAN; ESIRINGU ILKER; SAHIN YASEMIN; GULCAN H OZAN; NOBEL ILAÇ SANAYII VE TICARET A S 摘要:We have developed a new method for the synthesis of Rasagiline (Formula 1) based on the alkylation of trifluoroacetyl protected aminoindan. This protection enabled us to carry out an alkylation of aminoindan with a high yield and purity under very mild conditions with a wide range of reaction conditions and reagent selection. Considering the ease, purity and high yields of introducing and removal of the trifluoroacetyl group, this approach is a highly practical and economical way for the synthesis of rasagiline or its pharmaceutically acceptable salts.
专利号:US-9765077-B2 优先权日:2015-05-29 标题:Synthesis of duocarmycin analogues 发明人:STEPHENSON MICHAEL J; HOWELL LESLEY A; SEARCEY MARK 权利人:UNIV OF EAST ANGLIA 摘要:A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel intermediates and novel monomeric and extended duocarmycin analogues having amino acid substituents.
专利号:US-6310209-B1 优先权日:1997-12-08 标题:Synthesis of CC-1065/duocarmycin analogs 发明人:BOGER DALE L 权利人:SCRIPPS RESEARCH INST 摘要:The present invention relates to a method for the synthesis of the dihydroindole C-ring found in CC-1065/duocarmycin analogs.
专利号:US-2009088576-A1 优先权日:2006-01-30 标题:Process for the Stereoselective Preparation of Alcohols From Alpha, Beta-Insaturated Compounds 发明人:HEROLD PETER; STUTZ STEFAN; MAH ROBERT; STOJANOVIC ALEKSANDAR; LYOTHIER ISABELLE; BEHNKE DIRK; SPINDLER FELIX; BAPPERT ERHARD 权利人:HEROLD PETER; STUTZ STEFAN; MAH ROBERT; STOJANOVIC ALEKSANDAR; LYOTHIER ISABELLE; BEHNKE DIRK; SPINDLER FELIX; BAPPERT ERHARD 摘要:A process for the synthesis of an alcohol of formula (I), using as intermediate a compound of formula (V).
专利号:US-8541524-B2 优先权日:2006-07-04 标 题 :Free-radical polymerization process in aqueous dispersion for the preparation of a block copolymer at least one block of which is a block of a halogenated polymer 发明人:FRINGANT CHRISTOPHE; VANDERVEKEN YVES; LACROIX-DESMAZES PATRICK; TONNAR JEFF 权利人:FRINGANT CHRISTOPHE; VANDERVEKEN YVES; LACROIX-DESMAZES PATRICK; TONNAR JEFF; SOLVAY 摘要:Process of controlled free-radical polymerization in aqueous dispersion for the preparation of a block copolymer at least one block of which is a block of a halogenated polymer using molecular iodine and at least one oxidant whose solubility in water is at least 10 g/l for the synthesis of the first block of the block copolymer.
专利号:WO-2024003514-A1 优先权日:2022-06-29 标题 :Methods and compositions relating to the synthesis of the qs-7 molecule 发明人:OSBOURN ANNE; REED JAMES; ORME ANASTASIA; MARTIN LAETITIA 权利人:PLANT BIOSCIENCE LTD 摘要:The present invention relates to a biosynthetic route to precursors of the QS-7 molecule, as well as routes to make the QS-7 molecule, enzymes involved, the products produced and uses of the product.
摘要:Haufe, G., Science of Synthesis Knowledge Updates, (2019) 3, 182. 摘要:Zhao, L.; Li, C.-J., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 307. 摘要:American Industrial Hygiene Association Journal., 38(217), 1977 [] 摘要:Fundamental and Applied Toxicology., 8(562), 1987 摘要:Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure, Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982, -(48), 1982