CAS: 904326-93-8; 6-Morpholino-3-Pyridineboronic Acid

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485799-04-0 1191062-85-7 1218790-86-3

上下游产品

CAS号200064-11-5 5-溴-2-吗啉吡啶 | CAS号24255-25-2 2-吗啉基吡啶 | CAS号26820-62-2 2-吗啉基-5-硝基吡啶 | CAS号24255-27-4 4-(3-硝基-2-吡啶基)吗啉

📜4-(5-溴吡啶-2-基)吗啉置于正丁基锂,硼酸三异丙酯体系中,用 乙醚,正己烷 作为反应溶剂,化学反应 4.0H,反应生成 6-(4-吗啉基)-3-吡啶硼酸
参考文献:新型的双芳基取代的噻唑和恶唑类化合物是高活性和选择性的过氧化物酶体增殖物激活受体δ激动剂.
标题:新型的双芳基取代的噻唑和恶唑类化合物是高活性和选择性的过氧化物酶体增殖物激活受体δ激动剂.
摘要:从高通量筛选到高效和选择性的过氧化物酶体增殖物激活受体δ(pparδ)激动剂的发现,合成和优化了化合物1.详细介绍了该系列中的合成和构效关系.基于通用的ppar药效团模型示意图,支架1将其分为头基,接头和尾基,并使用体外ppar反式激活分析对ppar激活进行了优化.有效和选择性的pparδ活化需要一个(2-甲基苯氧基)乙酸头基,一个柔性连接基和一个带有两个疏水性芳基取代基的五元杂芳族中心环.这些芳基取代基的微调导致了一系列高效且选择性的化合物(例如化合物38C)在小鼠体内表现出出色的药代动力学特性.在体内急性给药模型中,该阵列的选定成员显示出可诱导丙酮酸脱氢酶激酶4(pdk4)和解偶联蛋白3(ucp3)的表达,这些基因已知参与能量稳态并受其调节.骨骼肌中的pparδ.
DOI:10.1021/jm9007399

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-11066447-B2
优先权日:2016-08-08
标 题:Aureobasidium derivatives and methods of synthesis
发明人：WUTS PETER; ELHAMMER AKE P
权利人:AUREOGEN BIOSCIENCES INC; AUEROGEN BIOSCIENCES INC
摘要:In general, the invention relates to AbA derivatives that are useful for treating infection. These novel compounds are shown to be effective in treating various fungal infections. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various fungal infections.

专利号:US-9988371-B2
优先权日:2014-06-03
标 题:Benzimidazole analogues and related methods
发明人：LI HONG-YU; FRETT BRENDAN; SANTORO MASSIMO; CARLOMAGNO FRANCESCA
权利人:UNIV ARIZONA; UNIV FEDERICO II; UNIV ARIZONA
摘要:The invention relates to compounds of the formula (VIII) wherein the moieties R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.

专利号:WO-2018031521-A1
优先权日:2016-08-08
标 题:Aureobasidium derivatives and methods of synthesis

专利号:US-2019292225-A1
优先权日:2016-08-08
标 题:Aureobasidium derivatives and methods of synthesis