CAS: 6628-86-0; 5-Chloro-2-Nitrobenzaldehyde

上下游产品

CAS号51282-49-6 5-氯-2-硝基苯甲酸甲酯 | CAS号587-04-2 3-氯苯甲醛 | CAS号73033-58-6 5-氯-2-硝基苄醇 | CAS号89303-10-6 2-(benzenesulfo... | CAS号100-00-5 对硝基氯苯 | CAS号2516-95-2 5-氯-2-硝基苯甲酸 | CAS号99-61-6 间硝基苯甲醛 | CAS号7664-93-9 硫酸 | CAS号1072913-31-5 1-(5-chloro-2-n... | CAS号395-81-3 5-氟-2-硝基苯甲醛 | CAS号17422-32-1 5-氯吲哚 | CAS号92-46-6 6-氯-2-甲基喹啉 | CAS号4792-67-0 5-氯吲哚-2-羧酸乙酯 | CAS号719-59-5 2-氨基-5-氯二苯甲酮 | CAS号35212-96-5 5-氯-1-苯并噻吩-2-羧酸甲酯 | CAS号26908-35-0 1,3-Dioxolane,2... | CAS号23746-76-1 5-氯-2-苯-1H-吲哚 | CAS号18672-02-1 2-氨基-6-氯喹啉

5-Chloro-2-Nitrobenzylidene Dichloride置于甲酸体系中,用 水 作为反应溶剂,以60%的收率获得产物5-氯-2-硝基苯甲醛
参考文献:通过氢的亲核取代直接取代硝基芳烃
标题:通过氢的亲核取代直接取代硝基芳烃
摘要:描述了一种通过氢被二氯甲基取代的亲核取代反应合成硝基芳香醛的新方法.
DOI:10.1016/s0040-4039(00)96274-9

专利信息

专利号:US-6448413-B1
优先权日:1999-06-10
标题:Process for the synthesis of a-nor-seco compounds with sterane skeleton
发明人：SANTA CSABA; TUBA ZOLTAN; MAHO SANDOR; SZELES JANOS; BALOGH GABOR; BRLIK JANOS; TRISCHLER FERENC; SZILAGYI GABRIELLA; BAKCSI ERIKA
权利人:RICHTER GEDEON VEGYESZET
摘要:The invention relates to a new process for the synthesis of 17β-hydroxy-17α-methyl-1,3-seco-2-nor-5α-androstane-3-acid derivatives of formula (I) n wherein the meaning of Z is carboxyl or formyl group and n to the new secoindoxylidene carboxylic acid derivatives of formula (II) n wherein R 1 and R 2 independently are C 1 -C 4 alkyl or alkoxy group, hydrogen or halogen atom—which are intermediates for preparing the compounds of formula (I). n The 17β-hydroxy-17α-methyl-1,3-seco-2-nor-5α-androstane-3-acid derivatives of formula (I) are intermediates in the synthesis of oxandrolon (17β-hydroxy-17α-methyl-2-oxa-5α-androstane-3-one), which is used as anabolic in therapy.

专利号:US-12247037-B2
优先权日:2018-12-12
标题:1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
发明人：BRANDT GARY
权利人:NEUMORA THERAPEUTICS INC
摘要:The present invention relates to 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds of Formula (I): wherein A, B, G, R1, R1b, RiC, R2 and X are as defined herein. The present compounds are vasopressin receptor antagonists (in particular of the Via receptor) for the treatment of neuro-psychological disorders, such as e.g. autism, anxiety, stress-related disorders, depression, schizophrenia or bipolar disorder. The present description discloses the synthesis of exemplary compounds, as well as pharmacological data thereof (e.g. pages 71 to 246; examples 1 to 49; tables 1 to 5). An exemplary compound is e.g. 8-chloro-1-(2-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (example 1, compound no. 1).

专利号:US-11040977-B2
优先权日:2013-12-05
标题 :Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[e]azulene and crytalline forms thereof
发明人：ROTHENHAEUSLER BENNO; TRUSSARDI RENE; HOFFMANN-EMERY FABIENNE; SCHWITTER URS; ADAM JEAN-MICHEL; GRASSMANN OLAF; HARTUNG THOMAS; RAN FREDERIC; DIODONE RALPH; PFLEGER CHRISTOPHE; BARTELS BJORN
权利人:HOFFMANN LA ROCHE
摘要:The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.

专利号:US-7301049-B2
优先权日:2001-06-21
标 题:Photolabile esters and their uses
发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
权利人:CANCER RES INST
摘要:Compounds which are capable of generating acid on photolysis are disclosed, and the uses of these compounds, especially for deprotecting the termini of nucleic acid molecules or peptides during synthesis of arrays. The compounds described herein may be employed in the detritylation of 5′-O-dimethoxytrityl (DMT) protected nucleotides by photolysing the compounds to generate an acid capable of removing the DMT group allowing oligonucleotide arrays to be synthesised using readily available 5′-O-DMT-nucleoside-3′-O-phosphoramidite monomers conventionally used in solid phase nucleic acid synthesis. A method of avoiding the effects of stray light in projection lithography techniques is also disclosed.

专利号:US-11040939-B1
优先权日:2020-06-23
标 题 :N-transfer reagent and method for preparing the same and its application
发明人：CHOU HO-HSUAN; LU GUAN-HAN; HSUEH HSIAO-CHIN; HUANG TZU-CHIA
权利人:UNIV NAT CHENG KUNG
摘要:Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): n n n n n n n n n n The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

专利号:US-2019194210-A1
优先权日:2013-12-05
标 题 :Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof