CAS: 641-77-0; (8S,9S,10R,11S,13S,14S,17R)-17-Acetyl-11,17-Dihydroxy-10,13-Dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-3H-Cyclopenta[a]Phenanthren-3-One (Hydrocortisone Impurity)

该化合物是一种类固醇激素,在调控各种生理过程方面起着关键作用,是蛋白酮的衍生物,具有特定的结构性特征,包括11和17个位置和3和20位位置的氢氧基质,以及3和20位位置的氯酮.该化合物主要与其他类固醇激素的生物合成有关,并且对生殖健康,特别是怀孕具有重大意义.该化合物合成在肾上腺和甲状腺中,并因其在保持妊娠和调节月经周期方面的作用而闻名.在临床环境中,17-羟丙酸酯被用于治疗性治疗,以防止在风险怀孕中早产.该物质通常以各种形式施用,包括注射或口服配方.其药理效应通过与特定类固醇激素摄取器的相互作用来调节,影响基因表达和细胞活动.在各种生理病理学上,受各种病理和生理病理影响.

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14760-49-7 604-09-1 1625-39-4

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CAS号33767-06-5 11β,17α-dihydro... | CAS号114585-39-6 3,3-ethanediyld... | CAS号114160-28-0 4β-chloro-17-hy... | CAS号603-96-3 1-[(3R,5R,8S,9S... | CAS号74263-44-8 Pregnane-3,20-d... | CAS号641-78-1 Pregnane-11,20-...

合成工艺路线路线简述

    📜氢化可的松置于吡啶,碘,三苯基膦体系中,用 甲苯 作为反应溶剂,化学反应 6.0H,以79%的收率获得产物11Beta,17Alpha-二羟基-4-孕烯-3,20-二酮
    参考文献:无金属碘介导的αα位醇脱氧到吸电子基团
    标题:无金属碘介导的αα位醇脱氧到吸电子基团
    摘要:在 Pph3 和吡啶的存在下,使用亚化学计量的分子碘可将 α 位的伯醇和仲醇直接脱氧为各种活化的吸电子基团,包括酮,酯,酰胺,酰亚胺和腈基.
    DOI:10.1002/ejoc.201800051

    海关参考信息

    专利信息


    专利号:US-4269778-A
    优先权日:1978-12-01
    标 题:Process for the preparation of steroids
    发明人：TOROSSIAN DIERAN R; AUBARD GILBERT G
    权利人:SIPSY
    摘要:Process for the preparation of steroids. The steroid 21-thioesters are prepared by preparing the corresponding sulphonates in acetonic suspension and by reacting this suspension directly with a thiocarboxylate. Preparation of synthesis intermediates.

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    主要参考文献

    [参考文献]: Franks Rc. Plasma 17-Hydroxyprogesterone, 21-Deoxycortisol And Cortisol In Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. 1974;39(6):1099-1102.
    [参考文献]: F A Costa-Barbosa, Et Al. Zona Fasciculata 21-Hydroxysteroids And Precursor-To-Product Ratios In 21-Hydroxylase Deficiency: Further Characterization Of Classic And Non-Classic Patients And Heterozygote Carriers. J Endocrinol Invest. 2011 Sep;34(8):587-92.
    [参考文献]: Flávia A Costa-Barbosa, Et Al. Superior Discriminating Value Of Acth-Stimulated Serum 21-Deoxycortisol In Identifying Heterozygote Carriers For 21-Hydroxylase Deficiency. Clin Endocrinol (Oxf). 2010 Dec;73(6):700-6.
    [参考文献]: Franoise Paris, Et Al. Premature Pubarche In Mediterranean Girls: High Prevalence Of Heterozygous Cyp21 Mutation Carriers. Gynecol Endocrinol. 2010 May;26(5):319-24.
    [参考文献]: J Fiet, Et Al. Hirsutism And Acne In Women: Coordinated Radioimmunoassays For Eight Relevant Plasma Steroids. Clin Chem. 1994 Dec;40(12):2296-305.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1016/j.jpeds.2014.04.011
    摘要:Kamrath C, Hartmann MF, Boettcher C, Wudy SA. Reduced Activity of 11β-Hydroxylase Accounts for Elevated 17α-Hydroxyprogesterone in Preterms. The Journal of Pediatrics. 2014 Aug;165(2):280–4. doi: 10.1016/j.jpeds.2014.04.011.
    摘要:Milewicz A, Szymczak J, Tupikowska G, Grabinski M, Gruszka S. The effect of treatment with defined spleen dialysate on plasma levels of 21-deoxycortisol and 17-hydroxyprogesterone in women with polycystic ovary disease. Arzneimittelforschung. 1985;35(9):1465–8.
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