CAS: 618-58-6; 3,5-Dibromobenzoic Acid

上下游产品

CAS号650598-42-8 3,5-dibromo-4-t... | CAS号97165-77-0 3,5-二溴苄腈 | CAS号51329-15-8 3,5-二溴苯甲酸甲酯 | CAS号108-36-1 1,3-二溴苯 | CAS号650598-46-2 (2,6-dibromophe... | CAS号626-39-1 1,3,5-三溴苯 | CAS号606-00-8 2-氨基3,5-二溴苯甲酸甲酯 | CAS号68385-95-5 2-氨基-3,5-二溴苯腈 | CAS号1885-29-6 2-氨基苯甲腈 | CAS号609-85-8 2-氨基-3,5-二溴苯甲酸 | CAS号51329-15-8 3,5-二溴苯甲酸甲酯 | CAS号97165-77-0 3,5-二溴苄腈 | CAS号67973-20-0 3-溴-5-羟基-2,6-二硝基苯甲酸 | CAS号56990-02-4 3,5-二溴苯甲醛 | CAS号609-85-8 2-氨基-3,5-二溴苯甲酸 | CAS号99-10-5 3,5-二羟基苯甲酸 | CAS号14401-73-1 3,5-二溴苯乙酮 | CAS号145691-59-4 3,5-二溴苯甲醇 | CAS号157893-14-6 3-溴-5-甲氧基苯甲酸 | CAS号23950-59-6 3,5-dibromobenz...

3,5-二溴苯甲酸甲酯置于氢氧化钾体系中,用 甲醇,水 作为反应溶剂,化学反应 4.0H,以66%的收率获得产物3,5-二溴苯甲酸
参考文献:Laatsch,Hartmut; Pudleiner,Heinz,Liebigs Annalen Der Chemie,1989,P. 863-882
标题:Laatsch,Hartmut; Pudleiner,Heinz,Liebigs Annalen Der Chemie,1989,P. 863-882

专利信息

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-02068613-A1
优先权日:2001-02-28
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
权利人:UNIV LELAND STANFORD JUNIOR; KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-2002045220-A1
优先权日:1999-10-13
标题:Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. col. This achievement permits a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-10022454-B2
优先权日:2008-09-23
标 题 :Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis
发明人：PETERSEN SCOTT G
权利人:PETERSEN SCOTT G; LIPOSCIENCES LLC
摘要:Disclosed herein are compositions and methods for generating ribo-nucleic neutral (RNN) or deoxyribo-nucleic-neutral (DNN) polynucleotides with reduced anionic charge, for improved intracellular delivery. Also disclosed herein are methods of using RNN and DNN compositions.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:RU-2114829-C1
优先权日:1991-08-12
标题:1,2,4-substituted piperidines and a method of their synthesis, intermedium compounds of piperidone and a method of their synthesis, pharmaceutical composition based on new compounds