CAS: 61550-02-5; (Furan-2-Yloxy)Trimethylsilane

该化合物是一种有机硅化合物,其特点是存在一种由三甲基硅氧组组成的呋喃环替代的呋喃环,该化合物通常具有与呋喃衍生物和硅氧化合物相关的各种特性.呋喃环有助于其芳香性和潜在反应性,使其成为包括电益替代在内的各种化学反应的候选体.三甲基硅氧混合物组增强了该化合物在有机溶剂中的稳定性和溶解性,同时还具有诸如增加热稳定性和防水性等独特特性.该化合物可用于各种用途,包括用作有机合成,硅基材料的配制或聚合化学中的添加剂.其特定的再活性和相互作用可能受到硅氧组的存在的影响,该组的存在可以改变呋喃环的电子特性.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号75-77-4 三甲基氯硅烷 | CAS号497-23-4 2(5H)-呋喃酮 | CAS号27607-77-8 三氟甲磺酸三甲基硅酯 | CAS号98-00-0 糠醇 | CAS号999-97-3 六甲基二硅氮烷 | CAS号2786-02-9 furan-2-yl-lithium | CAS号5796-98-5 双(三甲基硅基)过氧化物 | CAS号996-50-9 |N|,|N|-二乙基三甲基硅烷基胺 | CAS号367-64-6 乙酸 | CAS号497-23-4 2(5H)-呋喃酮 | CAS号124083-30-3 3-butylfuran-2(... | CAS号18688-70-5 butyl 4-oxo°Ctanoate | CAS号3249-33-0 4-羰基己酸乙酯 | CAS号2407-43-4 2-hexen-4-olide | CAS号21053-98-5 2(3H)-Furanone,... | CAS号2833-30-9 5-乙氧基呋喃-2(5H)-酮 | CAS号131613-93-9 tert-butyl (4S)...

合成工艺路线路线简述

  • 合成目标产物 2-(Trimethylsilyloxy)Furan 主要起始原料 Chlorotrimethylsilane And 2(5H)-Furanone
  • (文献来源)合成步骤主要原料 Chlorotrimethylsilane 和 2(5H)-Furanone
📜三甲基氯硅烷,2(5H)-呋喃酮置于三乙胺,Zinc(II) Chloride体系中,化学反应生成 三甲硅氧基-2-呋喃
参考文献:五元氧,氮和硫杂环的单羟基衍生物的互变异构
标题:五元氧,氮和硫杂环的单羟基衍生物的互变异构
摘要:Cinetique De Cetomisation De Divers Enols Heterocycliques Generices Par Hydrolyse De Leurs 衍生出三甲基甲硅烷基.恒定不变的恒等式
DOI:10.1021/ja00196A046

专利信息


专利号:WO-9529150-A1
优先权日:1994-04-21
标 题 :Synthesis of prototypes for renin inhibitors
发明人:HANESSIAN STEPHEN
权利人:CIBA GEIGY AG; HANESSIAN STEPHEN
摘要:Prototype renin inhibitors having general structure (I), where n is 0-3 inclusive, A are either both hydrogen atoms or together are a single carbon-nitrogen bond, R1 is hydrogen, or hydrocarbylcarboxy wherein the hydrocarbyl entity is selected from the group consisting of alkyl of 1 to 6 carbon atoms or aralkyl of 7 to 10 carbon atoms, R2 and R3 or independently alkyl of 1 to 4 carbon atoms, R4 is alkyl of 1 to 6 carbon atoms or a substituent of aliphatic character such as, for example, butyl, 2-morpholinoethyl or 2-carbamoyl-2-methyl-propyl, R5 is selected from aromatics, substitued aromatics and heteroaromatics, substituted or unsubstituted cycloalkyls, cycloalkenes having 3 to 8 carbon atoms, with substituents selected from alkyl, alkoxy of 3 to 10 carbon atoms and alkoxy derivatives such as 3-methoxy-propyloxy, primary and secondary amides, alkyl derivatives, are prepared by novel multistep synthesis. Such compounds are valuable intermediates for the manufacture of pharmaceutical such as Renin inhibitors and HIV-protease inhibitors.

专利号:US-4973693-A
优先权日:1989-09-01
标 题 :Novel pentacyclic compound and stereoselective synthesis thereof
发明人:GOTO SHUNSUKE; FUKUYAMA TOHRU
权利人:GOTO SHUNSUKE; FUKUYAMA TOHRU
摘要:Novel pentacyclic compounds having antimicrobial and antitumor activity and a process for preparing the same. The pentacyclic compounds are also usefual as intermediates in the production of known tetracyclic antitumor compounds.

专利号:JP-2019043913-A
优先权日:2017-09-05
标题 :Process for the synthesis of epodimnolactam and its intermediates

专利号:CN-1147810-A
优先权日:1994-04-21
标 题:Synthesis of prototypes for renin inhibitors

专利号:CA-2188294-A1
优先权日:1994-04-21
标题:Synthesis of prototypes for renin inhibitors

专利号:EP-0756590-A1
优先权日:1994-04-21
标题:Synthesis of prototypes for renin inhibitors

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Aguilar, E.; López, L. A., Science of Synthesis Knowledge Updates, (2014) 2, 91.
摘要:Li, W.; Liu, X. H.; Feng, X. M., Science of Synthesis Knowledge Updates, (2021) 1, 11.
摘要:Smith, L. H. S.; Coote, S. C.; Procter, D. J., Science of Synthesis Knowledge Updates, (2010) 3, 490.
摘要:Schneider, C.; Sickert, M., Science of Synthesis Knowledge Updates, (2017) 3, 341.
摘要:Schneider, C.; Sickert, M., Science of Synthesis Knowledge Updates, (2017) 3, 346.
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