📜三甲基氯硅烷,2(5H)-呋喃酮置于三乙胺,Zinc(II) Chloride体系中,化学反应生成 三甲硅氧基-2-呋喃 参考文献:五元氧,氮和硫杂环的单羟基衍生物的互变异构 标题:五元氧,氮和硫杂环的单羟基衍生物的互变异构 摘要:Cinetique De Cetomisation De Divers Enols Heterocycliques Generices Par Hydrolyse De Leurs 衍生出三甲基甲硅烷基.恒定不变的恒等式 DOI:10.1021/ja00196A046
专利信息
专利号:WO-9529150-A1 优先权日:1994-04-21 标 题 :Synthesis of prototypes for renin inhibitors 发明人:HANESSIAN STEPHEN 权利人:CIBA GEIGY AG; HANESSIAN STEPHEN 摘要:Prototype renin inhibitors having general structure (I), where n is 0-3 inclusive, A are either both hydrogen atoms or together are a single carbon-nitrogen bond, R1 is hydrogen, or hydrocarbylcarboxy wherein the hydrocarbyl entity is selected from the group consisting of alkyl of 1 to 6 carbon atoms or aralkyl of 7 to 10 carbon atoms, R2 and R3 or independently alkyl of 1 to 4 carbon atoms, R4 is alkyl of 1 to 6 carbon atoms or a substituent of aliphatic character such as, for example, butyl, 2-morpholinoethyl or 2-carbamoyl-2-methyl-propyl, R5 is selected from aromatics, substitued aromatics and heteroaromatics, substituted or unsubstituted cycloalkyls, cycloalkenes having 3 to 8 carbon atoms, with substituents selected from alkyl, alkoxy of 3 to 10 carbon atoms and alkoxy derivatives such as 3-methoxy-propyloxy, primary and secondary amides, alkyl derivatives, are prepared by novel multistep synthesis. Such compounds are valuable intermediates for the manufacture of pharmaceutical such as Renin inhibitors and HIV-protease inhibitors.
专利号:US-4973693-A 优先权日:1989-09-01 标 题 :Novel pentacyclic compound and stereoselective synthesis thereof 发明人:GOTO SHUNSUKE; FUKUYAMA TOHRU 权利人:GOTO SHUNSUKE; FUKUYAMA TOHRU 摘要:Novel pentacyclic compounds having antimicrobial and antitumor activity and a process for preparing the same. The pentacyclic compounds are also usefual as intermediates in the production of known tetracyclic antitumor compounds.
专利号:JP-2019043913-A 优先权日:2017-09-05 标题 :Process for the synthesis of epodimnolactam and its intermediates
专利号:CN-1147810-A 优先权日:1994-04-21 标 题:Synthesis of prototypes for renin inhibitors
专利号:CA-2188294-A1 优先权日:1994-04-21 标题:Synthesis of prototypes for renin inhibitors
专利号:EP-0756590-A1 优先权日:1994-04-21 标题:Synthesis of prototypes for renin inhibitors