CAS: 59786-31-1; Methyl 3-Bromoisonicotinate

相似化合物

13959-02-9 146679-66-5 70201-43-3

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CAS号67-56-1 甲醇 | CAS号13959-02-9 3-溴异烟酸 | CAS号124-38-9 二氧化碳 | CAS号74-88-4 碘甲烷 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号3034-31-9 N-苯基异烟酰胺 | CAS号71541-34-9 3-bromoisonicot... | CAS号626-55-1 3-溴吡啶 | CAS号18631-22-6 5H-Indeno[1,2-c... | CAS号104096-15-3 3-苯基吡啶-4-羧酸 | CAS号36106-47-5 3-氰基异烟酸甲酯 | CAS号13341-16-7 methyl 3-ethylp... | CAS号850162-87-7 3-Phenylpyridin...

异烟酰苯胺置于盐酸,正丁基锂,碳酸氢钠,1,2-二溴乙烷体系中,化学反应 19.0H,反应生成 3-溴异烟酸甲酯
参考文献:有机锂化合物在有机合成中的应用.十九.基于芳香金属化的合成策略.3-卤代吡啶甲酸和异烟酸的简明区域特异性合成
标题:有机锂化合物在有机合成中的应用.十九.基于芳香金属化的合成策略.3-卤代吡啶甲酸和异烟酸的简明区域特异性合成
摘要:摘要 通过苯胺 (1) 和 (2) 的金属化 (N-Buli),然后反应生成的双锂化苯胺与卤化剂 (Ccl3描述了-Ccl3,Ch2Br-Ch2Br,I2),随后对(3) 和(4) 进行酸性水解,作为将甲基吡啶和异烟碱酸区域特异性转化为其c3 卤代衍生物的一种方式.
DOI:10.1080/00397919708003053

专利信息

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.