专利号:WO-2015087228-A1 优先权日:2013-12-10 标 题 :Process for the preparation of cabazitaxel and its solvates 发明人:SETHI MADHURESH KUMAR; MAHAJAN SANJAY; MARA BHAIRAIAH; VEERA UPENDRANATH 权利人:MYLAN LAB LTD 摘要:The present disclosure provides anisole and benzyl alcohol solvates of cabazitaxel and methods of their production. The solvates may be characterized by powder x-ray diffraction patterns. The present disclosure also provides methods for the synthesis of cabazitaxel.
专利号:US-4721788-A 优先权日:1985-07-12 标题:4-cyanopiperidine derivatives 发明人:YAMAUCHI HIROSHI; NOMOTO SEIICHIRO; SUGIYAMA ISAO; KOMATU YUUKI; KANAI TAKEO; TAKAYANAGI KEIZO; TANAKA YASUHIDE; KOIWA ATSUSHI; ENDOH SHINICHI 权利人:EISAI CO LTD 摘要:A novel 4-cyanopiperidine derivative, which is represented by the following general formula (I): ##STR1## wherein X means a halogen atom, or an acid addition salt thereof, is prepared by reacting N-(2-hydroxyethyl)-4-carbamoylpiperidine or an acid addition salt thereof with a dehydrating and halogenating agent; or by reacting 4-cyanopiperidine or a salt thereof with a compound represented by the following general formula (IV): n n X--CH.sub.2 CH.sub.2 --Y (IV) n n wherein X has the same meaning as defined above and Y denotes the same halogen atom as X or another halogen atom. The derivative is useful as intermediate for synthesis of quinuclidine derivative which is in turn useful as intermediate for the production of medicines, chemicals, etc.