CAS: 572-32-7; 5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-3,7-Dimethoxy-4H-Chromen-4-One

上下游产品

quercetol dimethyl sulfate diazomethane methyl iodide5,3'-dihydroxy-3,7,4'-trimethoxyflavone diacetate 3'-acetoxy-5-hydroxy-3,7,4'-trimethoxyflavone retusin S-(5'-adenosyl)-L-hom°Cysteine

📜6,8-Dibromo-3,7-O-Dimethyltamarixetin置于palladium 10% On Activated Carbon,氢气体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,20.0 °C,101.33 Kpa 条件下,反应 48.0H,以73%的收率获得产物5,3'-二羟基-3,7,4'-三甲氧基黄酮
参考文献:Semisynthesis Of Natural Flavones Inhibiting Tubulin Polymerization,From Hesperidin
标题:Semisynthesis Of Natural Flavones Inhibiting Tubulin Polymerization,From Hesperidin
摘要:Semisynthesis Of 5,3'-Dihydroxy-3,6,7,8,4'-Pentamethoxyflavone (1),A Natural Flavone That Binds With High Affinity To Tubulin,Was Performed From Hesperidin,The Very Abundant Citrus Flavanone,By A Five-Step Sequence. The Last Step Of The Synthesis Also Gave Rise To 5,3'-Dihydroxy-3,6,7,4'-Tetramethoxyflavone (= Casticin Or Vitexicarpin) (10),5,3'-Dihydroxy-3,7,8,4'-Tetramethoxyflavone (= Gossypetin 3,7,8,4'-Tetramethyl Ether) (11),And,Unexpectedly,5,7,3'-Trihydroxy-3,6,8,4'Tetramethoxyflavone (12) And 5,3'-Dihydroxy-8-Dimethylamino-3,6,7,4'-Tetramethoxyflavone (= 8-Dimethylaminocasticin) (13). Cytotoxicity And Antitubulin Activity Of These Five Flavones,As Well As 5,3'-Dihydroxy-3,7,4'-Trimethoxyflavone (= Ayanin) (14) And Intermediate 6,8-Dibromo-Ayanin (8),Were Evaluated. Comparison Of The Responses Confirmed And Clarified The Influence Of The A-Ring Substitution Pattern On The Biological Activity.
DOI:10.1021/np100065V

专利信息

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.