CAS: 55750-63-5; 2,5-Dioxopyrrolidin-1-Yl 6-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Hexanoate

相似化合物

2918779-19-6 2389064-41-7 215312-86-0

上下游产品

CAS号74124-79-1 N,N'-二琥珀酰亚胺基碳酸酯 | CAS号55750-53-3 6-马来酰亚氨基己酸 | CAS号108-31-6 顺酐 | CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号60-32-2 6-氨基己酸 | CAS号57079-14-8 (Z)-6-(3-羧基丙烯酰胺)己酸 | CAS号159857-80-4 MC-Val-Cit-PAB

5-氨基颉草酸置于2,4,6-三甲基吡啶,三氟乙酸酐体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 3.0H,反应生成 6-(马来酰亚胺基)己酸琥珀酰亚胺酯
参考文献:叠氮化物-炔烃环加成反应可对核酸进行普遍的合成后修饰并有效合成生物活性核酸结合物†
标题:叠氮化物-炔烃环加成反应可对核酸进行普遍的合成后修饰并有效合成生物活性核酸结合物†
摘要:核酸的区域选择性合成后修饰对于科学和应用研究这些分子是必不可少的.在这里,我们通过利用通用的磷酰胺化反应将炔基/叠氮基区域选择性地掺入在5'末端用磷酸引发的合成后核酸中,报告了一种简便的通用方法.在有或没有铜的情况下,对修饰的核酸进行叠氮化物-炔烃环加成反应,以提供高收率的各种核酸偶联物,包括肽-寡核苷酸偶联物(poc).poc接种了人a549细胞,尽管由于少量残留的铜螯合到poc而引起细胞变形,但仍具有出色的细胞穿透能力.因此,磷酰胺化和叠氮化物-炔烃环加成反应的结合提供了一种通用的区域选择性策略,以在合成后修饰核酸.这项研究还阐明了用于生物系统的合成生物共轭物中残留铜的毒性.
DOI:10.1039/c4Ob01132E

专利信息

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.

专利号:WO-03064360-A1
优先权日:2002-02-01
标 题:Synthetic tetraethers and synthesis strategies therefor
发明人：KUEHL CHRISTINE; LITTGER RALF
权利人:BERNINA BIOSYSTEMS GMBH; KUEHL CHRISTINE; LITTGER RALF
摘要:The invention relates to novel synthetic tetraethers and a novel method for producing said substances. The inventive tetraethers are characterised in that they can be modified in a simple and targeted manner according to said synthesis method, which enabling the synthesis of the desired model substances. The synthesis concept guarantees high variability with simple individual production.

专利号:WO-2024186075-A1
优先权日:2023-03-03
标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
发明人：LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

专利号:US-10254287-B2
优先权日:2015-07-21
标题 :Protein fluorescent nanoparticles and methods of synthesis thereof
发明人：KUMAR CHALLA VIJAYA; STROMER BOBBI SHANYELLE
权利人:UNIV CONNECTICUT
摘要:Disclosed herein are stable and versatile protein nanoparticles having a range of tunable fluorescent properties. Such nanoparticles may find utility in biological imaging. Methods of synthesis of such nanoparticles are also disclosed.

专利号:US-2009162290-A1
优先权日:2005-09-09
标 题 :Method for the synthesis of penta-pendant enantiomer-pure chelators and process for therapeutically active bioconjugates preparation by a covalent binding thereof
发明人：BENES IVAN; CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
权利人:THERAPHARM GMBH
摘要:The present invention provides a method for synthesis and binding methods of pentapendant enantiomer-pure chelators of formula (VII) wherein R 1 , R 2 , R 3 , R 4 are groups forming an adequate enantiomer of the chelator; and X 1 -X 5 , Y 1 -Y 5 , Z 1 -Z 5 each individually forming pendant chelating groups.

专利号:US-5783674-A
优先权日:1989-02-17
标 题 :Method for the use and synthesis of peptides
发明人：GEYSEN HENDRIK MARIO
权利人:CHIRON CORP
摘要:A method for the separation of at least one specific binding entity from a mixture of binding entities by the steps of contacting a mixture of binding entities with immobilized peptides in which the peptides specifically bind to the specific binding entities and the peptides contain an amino acid which facilitates removal of the binding entities from the peptides, and separating the immobilized peptide/specific binding entity complexes from the mixture of binding entities. A change in incubation conditions facilitates removal of the binding entities from the immobilized peptides.