CAS: 52663-61-3; 2,2',3,5,5'-Pentachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,该家族由多氯替代物组成的双联苯分子组成,其特点是联苯结构附带五个氯原子,具体在2,2',3,5,5和5'位置上,其特点是具有疏水性,低挥发性,高热稳定性,使其耐受环境降解的影响. 2,2',3,5,5'-五氯苯通常被发现为无色的浅黄色固体,在水中不溶,但有机溶剂中可溶解.由于其持久性,它可以在生物生物中生物累积,并与环境和健康有关的各种关切,包括潜在的内分泌干扰和致癌影响有关.许多国家都实施了管制措施,以限制其使用并管理其环境影响,反映了围绕多氯联苯及其衍生物的更广泛关切.

英文名称2,2',3,5,5'-Pentachlorobiphenyl
中文名称2,2’,3,5,5’-戊氯联苯
IUPAC名称1,2,5-trichloro-3-(2,5-dichlorophenyl)benzene
其它别名2,2',3,5,5'-Pentachlorobiphenyl; 2,2',3',5,5'-Pentachlorobiphenyl; 2,3,5,2',5'-Pentachlorobiphenyl; 2,5,2',3',5'-Pentachlorobiphenyl; PCB 92
CAS编号52663-61-3
MFCD编号:MFCD00661147
FDA UNII编号:3GHX34QF3C
分子式:C12H5Cl5分子量:326.43
产品CID: 2496350
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: CRCBRZBVCDKPGA-UHFFFAOYSA-N
1S/C12H5Cl5/c13-6-1-2-10(15)8(3-6)9-4-7(14)5-11(16)12(9)17/h1-5H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

para-dichlorobenzene 2,3,5-trichloroaniline

合成工艺路线路线简述

📜1,4-二氯苯,三氯苯胺置于sodium Acetate,亚硝酸体系中,化学反应生成 2,2',3,5,5'-戊氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4