CAS: 495-42-1; (-)-Halostachine

上下游产品

α-(甲氨甲基)苯甲醇 2-(Methylamino)-1-Phenylethanol 6589-55-5
(R)-α-(氨基甲基)苄醇 (R)-2-Amino-1-Phenylethanol 2549-14-6
N-Methyl-2-Hydroxy-2-Phenylethanamide 65645-88-7
(R)-N-Methyl Mandelamide 89843-35-6
(R)-(-)-2-氯-1-苯乙醇 (R)-2-Chloro-1-Phenylethanol 56751-12-3
(R)-(+)-苯乙醇腈 (R)-Mandelonitrile 10020-96-9
(R)-环氧苯乙烷 (R)-Styrene Oxide 20780-53-4

📜(R)-(+)-苯乙醇腈置于三氯氧磷体系中,化学反应 0.75H,反应生成 盐穗草碱
参考文献:氰醇一锅还原-过渡-还原合成n-取代的β-乙醇胺
标题:氰醇一锅还原-过渡-还原合成n-取代的β-乙醇胺
摘要:描述了一种有效的(74%-97%的收率)三步一锅合成法,由o保护的旋光性氰醇合成(R)-海洛沙汀及其类似物.反应顺序包括将腈进行dibal还原为亚胺,将氨基磺酸酯化为仲亚胺,然后将硼氢化钠还原为相应的n-取代的β-乙醇胺.既可以得到o-保护的反应产物,也可以得到未保护的反应产物.
DOI:10.1016/s0040-4020(01)88477-5

专利信息

专利号:US-6046325-A
优先权日:1998-09-11
标 题:Chemical synthesis of 1,4-oxazin-2-ones
发明人：ASHWOOD MICHAEL STEWART; BISHOP BRIAN CHRISTOPHER; COTTRELL IAN FRANK
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a process for the preparation of a compound of formula (I): ##STR1## wherein R 1 is a C 1-6 alkyl or arylC 1-4 alkyl group; and R 2 is a hydrogen atom, a halogen atom, or a group selected from C 1-6 alkyl, CF 3 or C 1-6 alkoxy substituted by C 1-4 alkoxy; which comprises reacting an anhydrous or hydrated glyoxal of formula (II) with a compound of formula (III): ##STR2## in the presence of an acid.

专利号:US-9695211-B2
优先权日:2008-12-02
标题 :Method for the synthesis of phosphorus atom modified nucleic acids
发明人：WADA TAKESHI; SHIMIZU MAMORU
权利人:WAVE LIFE SCIENCES JAPAN INC
摘要:Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phosphonate moiety with a nucleoside/nucleotide.

专利号:US-2018111958-A1
优先权日:2008-12-02
标 题 :Method for the synthesis of phosphorus atom modified nucleic acids

专利号:CA-2744987-C
优先权日:2008-12-02
标 题 :Method for the synthesis of phosphorus atom modified nucleic acids

专利号:US-10329318-B2
优先权日:2008-12-02
标 题 :Method for the synthesis of phosphorus atom modified nucleic acids

专利号:US-2016347780-A1
优先权日:2008-12-02
标 题:Method for the synthesis of phosphorus atom modified nucleic acids