CAS: 3538-65-6; Butyric Acid Hydrazide

该化合物是一种有机化合物,其特点是存在氢氮化物功能组和丁氮酸混合物,一般是白色的对白固体,由于水和酒精等极地溶剂,如水和酒精,由于水和酒精具有水利特性,可溶于其中.该化合物的特性是碳oxylic酸(-NH-NH2)组,该组可影响其再活性及有机合成和药物的潜在应用.丁诺酸氢氮化物可能展示生物活动,使其对药用化学感兴趣,其熔点和沸点可能因纯度和特定条件而不同.此外,它可能参与各种化学反应,包括同较复杂的分子合成有关的电解和凝聚.在处理和储存时,应参考安全数据,如任何化学物质,以确保采取适当的预防措施.

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CAS号623-42-7 丁酸甲酯 | CAS号105-54-4 丁酸乙酯 | CAS号107-92-6 正丁酸 | CAS号3619-19-0 (E)-but-2-enehy... | CAS号10264-14-9 N-苄基丁酰胺 | CAS号541-35-5 丁酰胺 | CAS号10264-17-2 N-己基丁酰胺 | CAS号31130-16-2 5-丙基-1,3,4-噁二唑-2-硫醇 | CAS号13148-62-4 2-丙基-1,3,4-噁二唑 | CAS号1199-87-7 Butanamide,N-cy... | CAS号107-92-6 正丁酸 | CAS号123-72-8 正丁醛 | CAS号10264-16-1 Butanamide, N-butyl

合成工艺路线路线简述

    📜丁酸置于一水合肼,N,N'-二环己基碳二亚胺体系中,用 甲苯 作为反应溶剂,化学反应生成 丁酰肼
    参考文献:一种1,3,4-噻二唑衍生物的合成方法
    标题:一种1,3,4-噻二唑衍生物的合成方法
    摘要:本发明公开了一种1,3,4‑噻二唑衍生物的合成方法,包括:(1)以水合肼为原料,在催化剂作用下与酸进行反应得酰肼化合物ⅰ;(2)以氯甲酸烷基酯,硫氰酸盐在溶剂条件下反应,得到异硫氰酸酯化合物ⅱ;(3)在异硫氰酸酯化合物ⅱ的反应体系中,加含有化合物ⅰ的溶液,反应得含有化合物ⅲ的溶液;(4)化合物ⅲ的溶液经脱水,中和,水洗,得化合物ⅳ;(5)化合物ⅳ在缚酸剂和溶剂条件下加入卤代烷或硫酸二酯进行反应,得化合物ⅴ;(6)化合物ⅴ与伯胺进行胺化反应得1,3,4‑噻二唑衍生物ⅵ.本发明制备方法具备绿色无污染,操作简便,收率较高,反应条件温和等优点.

    海关参考信息

    专利信息


    专利号:US-10927095-B2
    优先权日:2017-08-14
    标 题:Processes for the preparation of Niraparib and intermediates thereof
    发明人：LUTHRA PARVEN K; VASOYA SANJAY L; PATIL BHATU T; TANEJA AMIT K; SRIVASTAV NAVEEN C; SINGH RINKU
    权利人:TEVA PHARMACEUTICALS INT GMBH
    摘要:The present invention relates to novel procedures and novel intermediates useful in the synthesis of Niraparib or any salt thereof.

    专利号:US-11518741-B2
    优先权日:2018-06-20
    标题 :Brivaracetam intermediate, preparation method therefor, and preparation method for brivaracetam
    发明人：YANG HANRONG; QI YANTAO; LI TAO; WANG BO
    权利人:SHANGHAI PUYI CHEMICAL CO LTD
    摘要:The present invention relates to a brivaracetam intermediate, a preparation method therefor, and a preparation method for brivaracetam. The steps of the method for preparing brivaracetam described in the present invention are short and the raw materials are cheap, moreover, the method is simple and highly effective without requiring isomer separation by means of column chromatography or asymmetric synthesis, being suitable for industrial large-scale production. In addition, disclosed by the present invention is a compound as shown in formula (II), which may be used for the synthesis of brivaracetam.

    专利号:US-4269773-A
    优先权日:1976-04-27
    标 题:Fused oxazolidine compounds
    发明人：MITSURU YOSHIOKA; TERUJI TSUJI; YASUHIRO NISHITANI; WATARU NAGATA
    权利人:SHIONOGI & CO
    摘要:Compounds represented by the following formula prepared from 6-aminopenicillanic acid are key intermediates in a stereo-specific synthesis of 1-oxadethiacephalosporins, highly active antibiotics: +TR [wherein COA and COB each is carboxy or protected carboxy; COX is carboxy, protected carboxy, or a group of the formula -COCQ=N2 or -COCHQ-Z (in which Q is hydrogen, lower alkyl or aryl; and Z is hydrogen or a nucleophilic group); Hal is halogen; R is lower alkyl or aralkyl; and Y is hydrogen or acyl].

    专利号:CN-109678752-A
    优先权日:2018-12-27
    标 题:A kind of method for asymmetric transformation and synthesis of L-2-aminobutanamide hydrochloride

    专利号:WO-9525714-A1
    优先权日:1994-03-23
    标 题 :Synthesis of compounds with predetermined chirality

    专利号:CN-103038208-B
    优先权日:2010-07-30
    标题 :Method for preparing 1-aryl-pyrazol-3-one intermediates for synthesis of sigma receptor inhibitors

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    合成参考文献


    摘要:Braverman, S.; Cherkinsky, M.; Birsa, M. L., Science of Synthesis, (2005) 18, 135.
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