CAS: 302-91-0; Allopregnane-3.α.,11.β.,17.α.,21-Tetrol-20-One
该化合物是一种通过4,5双环和3千吨组的酶氢化而形成的核质质溶解的减少代谢物,该化合物在类固醇新陈代谢中起着重要作用,并经常就其在溶胶活性和代谢途径中的影响进行研究,其结构改变会增强稳定性和改变受体相互作用,与cortisol相比,使其对内分泌学和药理学研究具有价值. Allo-3a-tetrahdro Cortiol对于分析应用特别有用,例如质量光谱学或免疫学学参考标准,因为它具有明确的化学特性,并且与类固醇荷尔蒙研究相关.
- 英文名称Allopregnane-3.α.,11.β.,17.α.,21-Tetrol-20-One
- 中文名称异体-3Α-四氢皮质醇
- 其它别名5a-Pregnan-20-one, 3a,11b,17,21-tetrahydroxy- (8CI); 3a,11b,17,21-Tetrahydroxy-5a-pregnan-20-one; 3a,11b,17a,21-Tetrahydroxy-5a-pregnan-20-one; 3a,5a-Tetrahydr°Cortisol; 5a-Pregnane-3a,11b,17a,21-tetraol-20-one; 5a-Pregnane-3a,11b,17a,21-tetrol-20-one; 5a-Tetrahydr°Cortisol; ATHF; Allo-3a-tetrahydr°Cortisol; Allopregnane-3a,11b,17a,21-tetrol-20-one; Allotetrahydr°Compound F; Allotetrahydr°Cortisol; Cortisol, allotetrahydro-; Kendall's compound C; Reichstein'ssubstance C; Wintersteiner's compound D; allo-Tetrahydr°Cortisol; a-THF
- CAS编号302-91-0
- MFCD编号:MFCD00003670
- EINECS号:206-131-1
- FDA UNII编号:A30U7U312E
- 分子式:C21H34O5分子量:366.49
- 产品CID: 1286368
- 产品分类有机原料 → 脂质和类脂质分子 → 类固醇和类固醇衍生物
物理性质
MSDS等安全信息
上下游产品
CAS号1242075-27-9 21-tert-butyldi... | CAS号50-23-7 氢化可的松合成工艺路线路线简述
📜21-Tert-Butyldimethylsilyloxy-3α,11β,17α-Trihydroxy-5α-Pregnan-20-One置于盐酸,水体系中,用 丙酮 用作溶剂,化学反应 0.17H,以96%的收率获得异体-3α-四氢皮质醇
参考文献:潜在的皮质激素代谢物:5α-和5β-系列中的3-氢和21-单硫酸盐及其双缀合物的四氢糖皮质激素的化学合成.
标题:潜在的皮质激素代谢物:5α-和5β-系列中的3-氢和21-单硫酸盐及其双缀合物的四氢糖皮质激素的化学合成.
摘要:在这里,我们描述了18种新颖的3-和21-单硫酸盐的完整化学合成及其在5Alpha-中的四氢皮质醇(thf),四氢-11-脱氧皮质醇(ths)和四氢可的松(the)的双共轭形式.和5Beta系列.涉及的主要反应是:(1)选择性保护底物中的特定羟基;(2)在c-5处将具有10%pd(oh)(2)/ C的delta(4)-3-酮类固醇在c-5催化加氢以生成3-Oxo-5Beta-类固醇并以10%pd / C进行还原异构化以产生3-氧代-5α-异构体; (3)用zn(bh(4))(2)和k-Selectride(R)将所得的3-Oxo-5Beta-和3-Oxo-5Alpha-类固醇还原为相应的3Alpha-羟基化合物,分别;
Doi:10.1248/cpb.58.344
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905399001-1,3-丙二醇
2905399002-1,4-丁二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12269839-B2
优先权日:2017-06-30
标题 :Chiral phosphoramidite auxiliaries and methods of their use
发明人：SAKAMURI SUKUMAR; BRADSHAW CURT W; LIU DINGGUO; ELTEPU LAXMAN
权利人:SIRIUS THERAPEUTICS INC
摘要:Disclosed are P-stereogenic groups that may be used in the synthesis of compounds including stereochemically enriched P-stereogenic phosphorothioates. P-stereogenic groups may be provided in nucleoside phosphoramidites including a sugar bonded to a nucleobase and to a stereochemically enriched phosphoramidite as well as methods of their use and methods of making them.
专利号:CN-118913615-A
优先权日:2024-07-16
标 题 :Flow field measurement method and system based on multi-color laser synthesis of new spectrum and light field imaging
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.1210/jcem-18-11-1285
摘要:ROMANOFF LP, RODRIGUEZ RM, SEELYE JM, PARENT C, PINCUS G. THE URINARY EXCRETION OF ETRAHYDROCORTISOL, 3α-ALLOTETRAHYDROCORTISOL AND TETRAHYDROCORTISONE IN YOUNG AND ELDERLY MEN AND WOMEN*. The Journal of Clinical Endocrinology & Metabolism. 1958 Nov;18(11):1285–95. doi: 10.1210/jcem-18-11-1285.
参考文献:10.1111/j.1523-1755.2004.00626.x
摘要:Kerstens MN, van der Kleij FG, Boonstra AH, Sluiter WJ, van der Molen JC, Navis G, Dullaart RP. Angiotensin administration stimulates renal 11 beta-hydroxysteroid dehydrogenase activity in healthy men. Kidney Int. 2004 Jun;65(6):2065–70. doi: 10.1111/j.1523-1755.2004.00626.x.
参考文献:10.1016/j.jchromb.2005.11.011
摘要:Raffaelli A, Saba A, Vignali E, Marcocci C, Salvadori P. Direct determination of the ratio of tetrahydrocortisol+allo-tetrahydrocortisol to tetrahydrocortisone in urine by LC-MS-MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 18;830(2):278–85. doi: 10.1016/j.jchromb.2005.11.011.
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