CAS: 215453-53-5; 7-Bromoisoquinolin-1-Amine

相似化合物

852570-80-0 215453-26-2 1192815-02-3

上下游产品

CAS号223671-15-6 7-溴-1-羟基异喹啉 | CAS号215453-51-3 7-溴-1-氯异喹啉 | CAS号215453-55-7 BENZAMIDE, N-[7... | CAS号862845-69-0 n-[7-(氯甲基)-1-异喹...

📜7-溴-1-氯异喹啉置于ammonium Hydroxide体系中,用 N-甲基吡咯烷酮 用作溶剂,化学反应 15.0H,以72.42%的收率获得7-溴-1-氨基异喹啉
参考文献: Aminopyridine Compounds And Methods For The Preparation And Use Thereof[fr] Composés Aminopyridine Et Procédés Pour Leur Préparation Et Leur Utilisation
标题: Aminopyridine Compounds And Methods For The Preparation And Use Thereof[fr] Composés Aminopyridine Et Procédés Pour Leur Préparation Et Leur Utilisation
摘要:本发明一般涉及治疗靶向细菌porphyromonas Gingivalis的治疗药物,包括其蛋白酶精氨酸龈蛋白酶a/b(rgp),以及它们用于治疗与p. Gingivalis感染相关的疾病,包括脑部疾病如阿尔茨海默病.在某些实施例中,本发明提供根据本文所述的formula I和formula Iii的化合物,以及其药用可接受的盐.

专利信息

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.