CAS: 21040-59-5; (S)-1-[(3,4-Dimethoxyphenyl)Methyl]-1,2,3,4-Tetrahydro-6-Methoxy-2-Methylisoquinolin-7-Ol

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      专利号:EP-3137618-A1
      优先权日:2014-04-29
      标 题 :Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds

      专利号:US-2017058305-A1
      优先权日:2014-04-29
      标 题:Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

      专利号:US-2021198706-A1
      优先权日:2014-04-29
      标题 :Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

      专利号:WO-2015164960-A1
      优先权日:2014-04-29
      标 题:Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds

      专利号:US-11613770-B2
      优先权日:2013-12-04
      标题:Compositions and methods for making (R)-reticuline and precursors thereof
      发明人:FACCHINI PETER JAMES; FARROW SCOTT CAMERON; BEAUDOIN GUILLAUME ARTHUR WELCH
      权利人:ANTHEIA INC
      摘要:Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.

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      主要参考文献


      1: Brochmann-Hanssen E, Nielsen B, Utzinger GE. Opium alkaloids. II. Isolation and characterization of codamine. J Pharm Sci. 1965 Oct;54(10):1531-2. doi: 10.1002/jps.2600541030. 51(2):308-20. doi: 10.1111/j.1556-4029.2006.00057.x. 142(1):61-9. doi: 10.1016/j.forsciint.2004.02.006. Corrected and republished in: Forensic Sci Int. 2004 Mar 10;140(2-3):175-83. 70(9):1536-8. doi: 10.1021/np070293a. Epub 2007 Sep 11. 1188(2):322-6. doi: 10.1016/j.chroma.2008.03.011. Epub 2008 Mar 18. 62(6):803-10. doi: 10.1021/np980311b. 140(2-3):175-83. doi: 10.1016/j.forsciint.2003.10.022. 14(6):703-8.

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      参考文献:10.1021/np50064a031
      摘要:Tantisewie B, Amurrio S, Guinaudeau H, Shamma M. New Bisbenzylisoquinolines from Stephania pierrii. J. Nat. Prod. 1989 Jul;52(4):846–51. doi: 10.1021/np50064a031.
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