欧盟法规
C&L通报上下游产品
7-iodoisatin meta-aminobenzoic acid 3-Iodobenzoic acid 2'-hydroxyimino-2-iodoacetanilide 2-(o-methyl phenoxymethyl)-8-iodo anthranil 2-(3,5-Dimethylphenoxymethyl)-8-iodoanthranil 8-Iodo-2-phenyl-benzo[d][1,3]oxazin-4-one 8-Iodo-2-phenoxymethyl-benzo[d][1,3]oxazin-4-one 7-碘吲哚满二酮置于sodium Hydroxide,双氧水体系中,化学反应生成2-氨基-3-碘苯甲酸
参考文献:Holt; Sadler,Proceedings Of The Royal Society Of London. Series B,Biological Sciences,1958,Vol. 148,P. 481,488
标题:Holt; Sadler,Proceedings Of The Royal Society Of London. Series B,Biological Sciences,1958,Vol. 148,P. 481,488
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专利信息
专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
专利号:US-2007021436-A1
优先权日:2005-06-10
标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
专利号:WO-2006135646-A1
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis
专利号:EP-1891040-A1
优先权日:2005-06-10
标题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis
专利号:US-2004138495-A1
优先权日:1997-10-09
标题:Combinatorial preparation of phosphorus-containing active compounds and intermediates by solid phase synthesis
发明人:HAAF KLAUS; PATEK MARCEL
权利人:HAAF KLAUS; PATEK MARCEL
摘要:The invention relates to solid phase processes for the systematic preparation of chemical compounds from the group of the phosphonous or phosphinic acids and/or derivatives thereof and the corresponding substance libraries which can be employed for test purposes, in particular tests for biological activity. The compounds n YR 1 P(â•?O)(OR 3 )R 2   (I) n in which Y, R 1 , R 2 , R 3 are as defined in claim 1 are prepared by reacting a resin-linker adduct (II) n [resin polymer]-[linker-Z-E 1 -S 1 ] n n in the presence of a suitable Pd catalyst with a phosphinate (III) n A 1 -O—(PHO)A â–¡   (III) n with substitution of the group S 1 to give the compound (IV) n [resin polymer]-[linker-Z-E 1 -P(H)(â•?O)—OA 1   (IV) n and cleaving the compound (I) after derivatization reactions on the resin from the resin-linker adduct. n The invention also provides the intermediate steps and resin-linked intermediate compounds and also the substance libraries obtained.
专利号:US-2003108944-A1
优先权日:1997-10-09
标 题 :Combinatorial preparations of phosphorus-containing active compounds and intermediates by solid phase synthesis