CAS: 178312-47-5; Ethyl 4,4-Difluorocyclohexanecarboxylate

相似化合物

122665-97-8 178312-48-6 265108-36-9

上下游产品

CAS号17159-79-4 4-氧代环己甲酸乙酯 | CAS号253276-02-7 ethyl 4-chlor°C... | CAS号90942-89-5 ethyl 4-hydroxy... | CAS号1072935-22-8 ethyl 4,4-bis(t... | CAS号810659-05-3 4,4-二氟环己基甲胺 | CAS号376348-65-1 马拉维若 | CAS号122665-97-8 4,4-二氟环己甲酸 | CAS号178312-48-6 (4,4-二氟环己基)甲醇 | CAS号265108-36-9 4,4-二氟环己基甲醛 | CAS号927209-98-1 4,4-二氟环己甲酰胺 | CAS号376348-75-3 4,4-二氟环己烷-1-甲酰氯

4-羰基环己羧酸置于氯化亚砜,二乙胺基三氟化硫体系中,用 四氯化碳 用作溶剂,化学反应 8.0H,反应生成乙基-4,4-二氟环己烷羧酸盐
参考文献: Spiro-Lactam Nmda Receptor Modulators And Uses Thereof[fr] Modulateurs Spiro-Lactames Des Récepteurs Nmda Et Leurs Utilisations
标题: Spiro-Lactam Nmda Receptor Modulators And Uses Thereof[fr] Modulateurs Spiro-Lactames Des Récepteurs Nmda Et Leurs Utilisations
摘要:揭示了具有调节nmda受体活性潜力的化合物.这些化合物可用于治疗抑郁症和相关疾病.还公开了口服制剂和其他药学上可接受的化合物给药形式,包括静脉注射制剂.

专利信息

专利号:WO-2008132128-A2
优先权日:2007-04-27
标 题 :Synthesis of a pharmaceutically active compound

专利号:US-9663516-B2
优先权日:2014-12-18
标题:Bicyclic-pyrimidinedione compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; EVANCHIK MARC; FOX JONATHAN CHARLES; GRILLO MARK; KANE BRIAN; MCDOWELL ROBERT; SONG YONGHONG; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.