CAS: 1780-36-5; 2,4,6-Trichloro-5-Methylpyrimidine

相似化合物

1780-31-0 3029-64-9 4316-97-6

上下游产品

trichlorophosphate 5-methylbarbituric acid 1-methyl-2,4,6-pyrimidinetrione 5-methylpyrimidine 2-chloro-5-methylpyrimidine 5-methyl-2,4,6-triaminopyrimidine 5-Brommethyl-2,4,6-trichlor-pyrimidin

5-甲基嘧啶-2,4,6(1H,3H,5H)-三酮置于苄基三乙基氯化铵,三氯氧磷体系中,化学反应 2.0H,反应生成2,4,6-三氯-5-甲基嘧啶
参考文献:[(2-Hydroxyethoxy)Methyl]-6-(Phenylthio)-Thymine 衍生物作为非核苷 Hiv-1 逆转录酶抑制剂的基于结构的设计:从 Hept 到亚磺酰基取代的 Hept
标题:[(2-Hydroxyethoxy)Methyl]-6-(Phenylthio)-Thymine 衍生物作为非核苷 Hiv-1 逆转录酶抑制剂的基于结构的设计:从 Hept 到亚磺酰基取代的 Hept
摘要:据报道,[(2-羟基乙氧基)甲基]-6-(苯硫基)胸腺嘧啶(Hept)类似物是一种很有前途的先导化合物,可作为非核苷类hiv-1逆转录酶抑制剂.在这项工作中,通过基于结构的设计策略设计了一系列新型亚磺酰基取代类似物,旨在提高 Hept 的活性,然后评估它们在 Mt-4 细胞中的抗 Hiv-1 活性.大多数最终化合物对野生型 Hiv-1 毒株 (Iii B ) 具有中等至强活性,Ec 50值在 0.21-1.91 μm 范围内,比参考化合物 Hept 好约 4 ∼ 32 倍.其中一些对临床相关的突变型 L100I 和 E138K 病毒表现出比 Nvp 更高的敏感性.进一步评估了所选化合物对野生型逆转录酶 (Rt) 的活性,其中大多数表现出纳摩尔活性,表明与基于细胞的活性具有非常好的相关性.化合物11H,11L和11Ab对野生型 Hiv-1 毒株(ec 50 = 0.280,0.209 和 0.290
Doi:10.1016/j.Bioorg.2022.105880

专利信息

专利号:US-2025304580-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:CA-2253382-A1
优先权日:1996-01-16
标题:Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules

专利号:US-2262735-A
优先权日:
标 题 :Synthesis of thiamin and product

专利号:AU-2009288632-B2
优先权日:2008-09-06
标 题:RNA synthesis - phosphoramidites for synthetic RNA in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic RNA at the 3' - end

专利号:AU-2009288632-A1
优先权日:2008-09-06
标 题 :RNA synthesis - phosphoramidites for synthetic RNA in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic RNA at the 3' - end

专利号:CN-116969993-A
优先权日:2023-06-05
标题 :A kind of continuous synthesis method of pyrimidine phosphonium methyl