CAS: 175711-83-8; 4'-Chloro-2'-Fluoroacetophenone

上下游产品

CAS号198967-23-6 4-氯-2-氟-N-甲氧基-N-甲基苯胺 | CAS号75-16-1 甲基溴化镁 | CAS号1229236-86-5 盐酸巴多昔芬 | CAS号856758-58-2 (AR)-4-氯-2-氟-A-甲基苯甲胺

3-氟乙酰苯胺置于盐酸,Aluminum (III) Chloride,Sodium Nitrite体系中,用 甲醇,二硫化碳,水 用作溶剂,化学反应 53.75H,反应生成4'-氯-2'-氟苯乙酮
参考文献:一种4-氯-2-氟-5-硝基苯乙酮的制备方法
标题:一种4-氯-2-氟-5-硝基苯乙酮的制备方法
摘要:本发明公开了一种4‑氯‑2‑氟‑5‑硝基苯乙酮的制备方法,其特征在于,以间氟苯胺为起始原料,经过乙酰化氨基保护,傅克酰基化反应,水解反应,桑德迈尔反应,最后硝化得到4‑氯‑2‑氟‑5‑硝基苯乙酮.本发明原料易得,反应条件要求低,副反应少,产率高.

专利信息

专利号:WO-2020248278-A1
优先权日:2019-06-14
标题:Method for continuous synthesis of substituted benzoic-acid organic substance
发明人：HONG HAO; ZHANG ENXUAN; LU JIANGPING; LIU ZHIQING; LI CHAO; TANG YANG
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.

专利号:CN-111019915-A
优先权日:2019-11-08
标 题:Application of carbonyl reductase mutants in the synthesis of chiral ortho-halogenated-α-phenylethanol

专利号:CN-111019915-B
优先权日:2019-11-08
标题:Application of carbonyl reductase mutants in the synthesis of chiral ortho-halogenated-α-phenylethanol

专利号:JP-4070407-B2
优先权日:1998-06-24
标 题 :Solid-phase synthesis of aldehydes, ketones, oximes, amines, hydroxamic acids or α, β-unsaturated carboxylic acids and aldehyde compounds

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof