CAS: 17419-81-7; 4-Hydroxycyclohexanecarboxylic Acid

上下游产品

4-羟基环己甲酸甲酯 Methyl 4-Hydroxycyclohexanecarboxylate 17449-76-2
1,3,5-三羧基戊烷 Pentane-1,3,5-Tricarboxylic Acid 6940-58-5
4-羟基环己烷甲酸乙酯 4-Hydroxycyclohexyl Carboxylic Acid Ethyl Ester 17159-80-7
4-羰基环己羧酸 4-Oxocyclohexanecarboxylic Acid 874-61-3

对羟基苯甲酸置于硫酸体系中,用 水 用作溶剂,以85%的收率获得4-羟基环己烷甲酸
参考文献:使用地球丰富的 Ni−moo2 异质结构催化剂选择性电化学加氢苯酚:氧空位对产物选择性的影响
标题:使用地球丰富的 Ni−moo2 异质结构催化剂选择性电化学加氢苯酚:氧空位对产物选择性的影响
摘要:Moo 2的加入提高了 Ni置于0.1 Mh 2 So 4水溶液中选择性电化学氢化苯酚的催化效率.原位漫反射红外光谱和密度泛函理论计算揭示了卓越性能的起源.
Doi:10.1002/anie.202214881

专利信息

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:WO-2018175954-A1
优先权日:2017-03-23
标 题 :Synthesis of imidazo[5,1-a]isoindole derivative useful as ido inhibitors
发明人：ANGELAUD REMY; BACHMANN STEPHAN; BEYELER ANDREAS; CARRERA DIANE; FISCHER ROLF; GUILLEMONT-PLASS MAUD; HOU HAIYUN; IDING HANS; KRAFT ANNE KATRIN; MANNS ANDREAS; MEIER ROLAND; NIEDERMANN KARIN; OLBRICH MARTIN; PIECHOWICZ KATARZYNA; REGE PANKAJ; REMARCHUK TRAVIS; SIROIS LAUREN; ST-JEAN FREDERIC; XU JIE
权利人:HOFFMANN LA ROCHE; HOFFMANN LA ROCHE; GENENTECH INC
摘要:Presently provided is a method of making a compound of the Formula (I) wherein X is halogen, which is useful for modulating the activity of indoleamine 2,3-dioxygenase (IDO) and treating diseases and conditions in which the inhibition of IDO mediated immunosuppression is beneficial.

专利号:US-5648484-A
优先权日:1995-03-07
标 题 :Catalytic enantioselective synthesis of a spriofused azetidinone
发明人：WU GUANG-ZHONG
权利人:SCHERING CORP
摘要:A process for producing a compound of the formula ##STR1## comprises the following sequence of steps: ##STR2## wherein the various radicals are as defined in the specification.

专利号:US-11040977-B2
优先权日:2013-12-05
标题 :Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[e]azulene and crytalline forms thereof
发明人：ROTHENHAEUSLER BENNO; TRUSSARDI RENE; HOFFMANN-EMERY FABIENNE; SCHWITTER URS; ADAM JEAN-MICHEL; GRASSMANN OLAF; HARTUNG THOMAS; RAN FREDERIC; DIODONE RALPH; PFLEGER CHRISTOPHE; BARTELS BJORN
权利人:HOFFMANN LA ROCHE
摘要:The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.

专利号:US-2019194210-A1
优先权日:2013-12-05
标 题 :Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof