CAS: 16948-10-0; 3-((Tert-Butoxycarbonyl)Amino)-2-Methylpropanoic Acid

该化合物是一种受保护的氨基酸衍生物,广泛用于丙酸合成和制药研究.乙氧碳基(Boc)组为矿能提供有效保护,使碳酸箱酸场地有选择地作出反应.其分支甲基组引入了可影响peptide相容性和稳定性的消毒效应.该化合物在固态聚氨酯合成(SPPS)中特别宝贵,因为它符合标准的脱硫条件.可以在温酸条件下清除乙酸衍生物,而不影响其他敏感的功能组.其高纯度和稳定性使它成为构建复杂的peptide和生物活性分子的可靠中间体.

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相似化合物

132696-45-8 144-90-1 190897-47-3

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CAS号10569-72-9 DL-3-氨基异丁酸水合物 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号1572-99-2 2-氰基丙酸乙酯 | CAS号16965-08-5 碳酸叔丁基-2,4,5-三氯苯酯 | CAS号312493-43-9 (2R)-2-Methyl-3... | CAS号357610-32-3 5-甲基-2,6-二氧代-[1...

合成工艺路线路线简述

    3-氨基异丁酸,二碳酸二叔丁酯置于potassium Carbonate体系中,用 1,4-二氧六环,水 用作溶剂,化学反应生成Boc-Dl-3-氨基异丁酸
    参考文献:通过在亚胺盐上添加双(o-甲硅烷基)乙烯酮缩醛一锅合成β-氨基酸衍生物
    标题:通过在亚胺盐上添加双(o-甲硅烷基)乙烯酮缩醛一锅合成β-氨基酸衍生物
    摘要:我们在这里报告我们关于合成β-氨基酸的新高效策略的发现,该策略涉及在曼尼希(mannich)型亚胺基亲电体上添加双(o-甲硅烷基)乙烯酮缩醛.
    Doi:10.1016/j.Tetlet.2007.09.119

    海关参考信息

    专利信息


    专利号:US-11530204-B2
    优先权日:2019-09-30
    标 题 :Biocatalytic synthesis of cryptophycin anticancer agents
    发明人:SHERMAN DAVID H; SCHMIDT JENNIFER J
    权利人:UNIV MICHIGAN REGENTS
    摘要:The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.

    专利号:WO-0010565-A1
    优先权日:1998-08-18
    标 题 :Growth hormone secretagogues
    发明人:DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
    权利人:LILLY CO ELI; DODGE JEFFREY ALAN; HAUSER KENNETH LEE; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR CHARLES WILLIS III; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROBERT LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
    摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

    专利号:WO-2021067460-A1
    优先权日:2019-09-30
    标题 :Biocatalytic synthesis of cryptophycin anticancer agents

    专利号:US-2022204495-A1
    优先权日:2019-05-03
    标题:Inhibiting trabid
    发明人:CAMPBELL ANNE-MARIE; MARCIN Lawrence; KAYSER-BRICKER KATHERINE
    权利人:VALO HEALTH INC; INTEGRAL HEALTH HOLDINGS LLC
    摘要:The present disclosure is directed to compounds of formulas (I)-(VII), which are useful as modulators of TRABID. The compounds are further useful in the inhibition of TRABID and the treatment of diseases or disorders associated with the inhibition of TRABID. For instance, the disclosure is concerned with compounds and compositions for inhibition of TRABID, methods of treating diseases associated with the inhibition of TRABID (e.g., autoimmune inflammatory diseases including, but not limited to, psoriasis), and methods of synthesis of these compounds.

    专利号:WO-0102375-A1
    优先权日:1999-07-01
    标 题:Process for synthesizing oxadiazoles
    发明人:DENER JEFFREY MARK; LY CUONG QUOC
    权利人:AXYS PHARM INC; DENER JEFFREY MARK; LY CUONG QUOC
    摘要:The present invention relates to a process for the synthesis of a single as well as large array of oxadiazole based organic compounds. These oxadiazole based organic compounds are represented by compounds of formula (I).

    专利号:EP-4038085-A1
    优先权日:2019-09-30
    标题 :Biocatalytic synthesis of cryptophycin anticancer agents
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    合成参考文献


    摘要:Primer, D. N.; Molander, G. A., Science of Synthesis, (2019) , 302.
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