专利号:US-4756739-A 优先权日:1985-12-21 标题 :Pyridine derivatives and the N-oxides thereof, and the use thereof as intermediates for the synthesis of plant protecting agents 发明人:FUSS ANDREAS; KOCH VOLKER 权利人:HOECHST AG 摘要:The compounds of the formula I (I) in which A denotes N or N->O, Z denotes O or NH, R denotes H, (halo)alkyl, (halo)alkenyl, (halo)alkynyl or alkoxycarbonyl, R1 denotes hydrogen, halogen, amino, -NHOH, hydroxyl, (substituted) phenylazo or a radical of the formulae Y=C=N-, Y1Y2C=N-, Y3NH- or K denotes 0 or 1, and m and n, independently of one another, denote a number from 1 to 4, with the proviso that, when Z-R denotes OH or NH2, (R1)n denotes at least one radical of the formula or represents two radicals, in the 5 or 6 position of the heterocyclic ring, which, in the 5 position, denote halogen and, in the 6 position, denote a radical of the group comprising halogen, amino, hydroxyl or phenylazo, which may be substituted as specified above, are valuable intermediates in the synthesis of plant protection agents.
专利号:US-12358877-B2 优先权日:2019-03-05 标题:Synthesis of 4-amino-5-methyl-1H-pyridin-2(1H)-on (intermediate compound for the synthesis of the MR antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine 发明人:PLATZEK JOHANNES; LOVIS KAI 权利人:BAYER AG; Bayer Pharma AG 摘要:The present invention relates to a novel and improved method for preparing 4-amino-5-methylpyridone of the formula (I)which is an intermediate in the preparation of the MR antagonist finerenone.
专利号:US-5110929-A 优先权日:1986-08-07 标题 :Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles 发明人:PARADIES HENRICH H 权利人:MEDICE CHAM PHARM FABRIK PUTTE 摘要:The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10-5 -10-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.
专利号:WO-9108265-A1 优先权日:1989-12-02 标 题:Azo compounds and their use as dyes, 1-sulpho-6-carboxyl-amino naphthaline, its use as a diazo component and process for the production of these compounds 发明人:SPRINGER HARTMUT; HUSSONG KURT 权利人:HOECHST AG 摘要:The description relates to azo compounds corresponding to formula (1) below, having fibre-reactive properties and making valuable dyes. They can dye hydroxy and/or carbonamide group-containing synthetic and natural materials, especially fibre materials, like wool and especially cellulose fibre materials in bright colours. Formula (1) in which: M is hydrogen or a salt-forming metal like an alkaline metal; K is a residue of general formulae (2A) or (2B) in which: E is the residue of an intermediate component common in disazo dyes which can act as a coupling and as a diazo component, e.g. the residue of a 1-(aminophenyl) or -amino-naphthyl) pyrazolon, aminonaphthol, anilin or 1-amino naphthalin compound; v is the figure zero or 1; K is the residue of a water-soluble coupling component, preferably from the naphthol, aminonaphthol, anilin, pyrazolon, hydroxypyridon and acetoacetyl arylide series, whereby this coupling component contains 1 or 2 fibre-reactive groups of the vinyl sulphonate series; D is a benzol or naphthalin residue, whereby its substituents R?1 and R?2 are common ones in azo dyes, e.g. (besides hydrogen) lower alkyl, lower alkoxy, halogen, sulpho and carboxyl; the group -SO2?-Y is a fibre-reactive group of the vinyl sulphone series; a is the figure zero, 1 or 2; and k is the number 1 or 2. A description is also given of the compound 2-amino naphthaline-1-sulphonic acid-6-carboxylic acid which may be used as a pre-product in the production of dyes, e.g. as diazo component in the synthesis of dyes of general formula (1).
专利号:US-2021293698-A1 优先权日:2020-01-23 标题 :Synthesis of gold nanoparticles functionalized with hydroxypyridinone chelators for metal sensing 发明人:PALLARES ROGER M; ABERGEL REBECCA J 权利人:UNIV CALIFORNIA 摘要:A colorimetric assay of lanthanide or actinide (f-block elements) samples and a sensing construct of functionalized gold nanoparticles are provided. The construct is a gold nanoparticle with hydroxypyridinone ligands on the surface. The colorimetric assay can be performed in two different ways: (1) Gold nanoparticles functionalized with hydroxypyridinone ligands are synthesized, and then added to the sample solution. The presence of f-block elements triggers the gold nanoparticle aggregation, which changes the solution color. (2) Exploiting the competition between Au3+ and cations with higher binding affinities, where the f-block elements quench the nanoparticle growth and affect the color of solution. In both methods, the change in color is used as a sensing principle to quantify the f-block element concentrations in aqueous solutions.
专利号:WO-2024112764-A1 优先权日:2022-11-21 标 题:Synthesis of pyrrolo[3,4-c]pyrroles 发明人:LUKE GEORGE P; RODRIGUEZ SONIA; OUELLET STEPHANE G; GORINS GILLES; DIKER KHALID; BEAUDENON AURÉLIE; COUSIN JONATHAN 权利人:NOVO NORDISK HEALTHCARE AG 摘要:Novel synthetic methods of making pyrrolo[3,4- c ]pyrroles, derivatives thereof, and intermediates thereto are provided. Also provided are methods using pyrrolo[3,4- c ]pyrroles in the processes for preparing bioactive compounds ( e.g. PKR Activating Compounds).
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合成参考文献
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