CAS: 16867-04-2; 2,3-Dihydroxypyridine

该化合物是一种有机化合物,其特征是2和3个位置上有两个附于一个环的环状氢氧(-OH)组,该化合物是含有一个氮原子的六人芳香热循环的派生物,六人芳香循环含有一个氮原子;氢氧基环体的存在增强了水中的溶解性,有助于其反应,使其成为有机合成的多用途中间体.2,3,3-二氢氧丙烯丙烯酸具有微弱酸等特性,可参与氢联结,从而影响其与其他分子的相互作用.该化合物常常用于合成各种药品和农用化学物质,以及协调化学活动,因为其具有切热金属离子的能力.此外,它可能展示生物活动,包括潜在的抗氧化剂特性.安全数据表明,与许多有机化合物一样,它应该谨慎处理,因为如果浸入或吸入,它可能会对健康造成危害.

结构式图片

相似化合物

5154-01-8 34206-49-0 175292-03-2

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CAS号98-01-1 糠醛 | CAS号613-75-2 (乙酰基氧基)(2-呋喃基)乙酸甲酯 | CAS号109-00-2 3-羟基吡啶 | CAS号63756-60-5 2,3-diethoxypyridine | CAS号142-08-5 2-羟基吡啶 | CAS号89694-54-2 2-溴-3-乙氧基吡啶 | CAS号63430-18-2 5-hydroxy-6-oxo... | CAS号13472-83-8 2-甲氧基-3-吡啶醇 | CAS号39658-49-6 四氢-2,5-二甲氧基-2-呋喃羧酸甲酯 | CAS号71847-96-6 (2-oxo-1H-pyrid... | CAS号111492-69-4 1-苄基-2,3-哌啶二酮 | CAS号33630-99-8 3-氨基-2-羟基吡啶 | CAS号24016-11-3 2(1H)-Pyridinon... | CAS号75710-99-5 3-甲氧基-5-硝基吡啶-2-醇 | CAS号316354-21-9 3-hydroxy-1-(4-... | CAS号30932-82-2 1-methylpiperid... | CAS号129421-32-5 2,3-二氢-1,4-二噁并[... | CAS号20928-63-6 3-甲氧基-2(1H)-吡啶酮 | CAS号19365-01-6 1-甲基-3-羟基-2(1H)-吡啶酮 | CAS号19365-08-3 3-羟基-2-哌啶酮

合成工艺路线路线简述

  • 合成目标产物 2,3-Dihydroxypyridine 主要起始原料 2-Hydroxypyridine
  • (文献来源)合成步骤主要原料 2-Hydroxypyridine
3-羟基-2-碘吡啶置于甲醇,氢溴酸体系中,化学反应生成吡啶-2,3-二醇
参考文献:V. Schickh Et Al.,Chemische Berichte,1936,Vol. 69,P. 2593,2604
标题:V. Schickh Et Al.,Chemische Berichte,1936,Vol. 69,P. 2593,2604

海关参考信息

专利信息


专利号:US-4756739-A
优先权日:1985-12-21
标题 :Pyridine derivatives and the N-oxides thereof, and the use thereof as intermediates for the synthesis of plant protecting agents
发明人:FUSS ANDREAS; KOCH VOLKER
权利人:HOECHST AG
摘要:The compounds of the formula I (I) in which A denotes N or N->O, Z denotes O or NH, R denotes H, (halo)alkyl, (halo)alkenyl, (halo)alkynyl or alkoxycarbonyl, R1 denotes hydrogen, halogen, amino, -NHOH, hydroxyl, (substituted) phenylazo or a radical of the formulae Y=C=N-, Y1Y2C=N-, Y3NH- or K denotes 0 or 1, and m and n, independently of one another, denote a number from 1 to 4, with the proviso that, when Z-R denotes OH or NH2, (R1)n denotes at least one radical of the formula or represents two radicals, in the 5 or 6 position of the heterocyclic ring, which, in the 5 position, denote halogen and, in the 6 position, denote a radical of the group comprising halogen, amino, hydroxyl or phenylazo, which may be substituted as specified above, are valuable intermediates in the synthesis of plant protection agents.

专利号:US-12358877-B2
优先权日:2019-03-05
标题:Synthesis of 4-amino-5-methyl-1H-pyridin-2(1H)-on (intermediate compound for the synthesis of the MR antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine
发明人:PLATZEK JOHANNES; LOVIS KAI
权利人:BAYER AG; Bayer Pharma AG
摘要:The present invention relates to a novel and improved method for preparing 4-amino-5-methylpyridone of the formula (I)which is an intermediate in the preparation of the MR antagonist finerenone.

专利号:US-5110929-A
优先权日:1986-08-07
标题 :Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles
发明人:PARADIES HENRICH H
权利人:MEDICE CHAM PHARM FABRIK PUTTE
摘要:The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10-5 -10-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.

专利号:WO-9108265-A1
优先权日:1989-12-02
标 题:Azo compounds and their use as dyes, 1-sulpho-6-carboxyl-amino naphthaline, its use as a diazo component and process for the production of these compounds
发明人:SPRINGER HARTMUT; HUSSONG KURT
权利人:HOECHST AG
摘要:The description relates to azo compounds corresponding to formula (1) below, having fibre-reactive properties and making valuable dyes. They can dye hydroxy and/or carbonamide group-containing synthetic and natural materials, especially fibre materials, like wool and especially cellulose fibre materials in bright colours. Formula (1) in which: M is hydrogen or a salt-forming metal like an alkaline metal; K is a residue of general formulae (2A) or (2B) in which: E is the residue of an intermediate component common in disazo dyes which can act as a coupling and as a diazo component, e.g. the residue of a 1-(aminophenyl) or -amino-naphthyl) pyrazolon, aminonaphthol, anilin or 1-amino naphthalin compound; v is the figure zero or 1; K is the residue of a water-soluble coupling component, preferably from the naphthol, aminonaphthol, anilin, pyrazolon, hydroxypyridon and acetoacetyl arylide series, whereby this coupling component contains 1 or 2 fibre-reactive groups of the vinyl sulphonate series; D is a benzol or naphthalin residue, whereby its substituents R?1 and R?2 are common ones in azo dyes, e.g. (besides hydrogen) lower alkyl, lower alkoxy, halogen, sulpho and carboxyl; the group -SO2?-Y is a fibre-reactive group of the vinyl sulphone series; a is the figure zero, 1 or 2; and k is the number 1 or 2. A description is also given of the compound 2-amino naphthaline-1-sulphonic acid-6-carboxylic acid which may be used as a pre-product in the production of dyes, e.g. as diazo component in the synthesis of dyes of general formula (1).

专利号:US-2021293698-A1
优先权日:2020-01-23
标题 :Synthesis of gold nanoparticles functionalized with hydroxypyridinone chelators for metal sensing
发明人:PALLARES ROGER M; ABERGEL REBECCA J
权利人:UNIV CALIFORNIA
摘要:A colorimetric assay of lanthanide or actinide (f-block elements) samples and a sensing construct of functionalized gold nanoparticles are provided. The construct is a gold nanoparticle with hydroxypyridinone ligands on the surface. The colorimetric assay can be performed in two different ways: (1) Gold nanoparticles functionalized with hydroxypyridinone ligands are synthesized, and then added to the sample solution. The presence of f-block elements triggers the gold nanoparticle aggregation, which changes the solution color. (2) Exploiting the competition between Au3+ and cations with higher binding affinities, where the f-block elements quench the nanoparticle growth and affect the color of solution. In both methods, the change in color is used as a sensing principle to quantify the f-block element concentrations in aqueous solutions.

专利号:WO-2024112764-A1
优先权日:2022-11-21
标 题:Synthesis of pyrrolo[3,4-c]pyrroles
发明人:LUKE GEORGE P; RODRIGUEZ SONIA; OUELLET STEPHANE G; GORINS GILLES; DIKER KHALID; BEAUDENON AURÉLIE; COUSIN JONATHAN
权利人:NOVO NORDISK HEALTHCARE AG
摘要:Novel synthetic methods of making pyrrolo[3,4- c ]pyrroles, derivatives thereof, and intermediates thereto are provided. Also provided are methods using pyrrolo[3,4- c ]pyrroles in the processes for preparing bioactive compounds ( e.g. PKR Activating Compounds).
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主要参考文献

[参考文献]: Anton Granzhan, Et Al. Connection Of Metallamacrocycles Via Dynamic Covalent Chemistry: A Versatile Method For The Synthesis Of Molecular Cages. J Am Chem Soc. 2011 May 11;133(18):7106-15.
[参考文献]: Elham Y Hashem, Et Al. Solvent Effects On The Electronic Absorption Spectra And Acid Strength Of Some Substituted Pyridinols. Spectrochim Acta A Mol Biomol Spectrosc. 2002 Jan 15;58(2):239-47.
[参考文献]: Jennifer A Jacobsen, Et Al. Identifying Chelators For Metalloprotein Inhibitors Using A Fragment-Based Approach. J Med Chem. 2011 Jan 27;54(2):591-602.
[参考文献]: M Sugawara, Et Al. Antithyroid Effect Of 2,3-Dihydroxypyridine In Vivo And In Vitro. Proc Soc Exp Biol Med. 1982 Sep;170(4):431-5.
[参考文献]: Nanting Ni, Et Al. Pyrogallol And Its Analogs Can Antagonize Bacterial Quorum Sensing In Vibrio Harveyi. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1567-72.

合成参考文献


摘要:D. P. Goel, Y. Dutt and R. P. Singh, J. Inorg. Nucl. Chem. 32, 3119 (1970).
摘要:c E. Spinner and G.B. Yeoh. J. Chem. Soc., B 1971, 296.
摘要:Tang, R.-Y., Science of Synthesis: Knowledge Updates, (2024) 1, 339.
参考文献:10.1007/bf02784555
摘要:Yokel RA. Aluminum chelation by 3-hydroxypyridin-4-ones in the rat demonstrated by microdialysis. Biol Trace Elem Res. 1996;53(1-3):193–203. doi: 10.1007/bf02784555.
参考文献:10.1002/1521-3765(20010803)7:15<3196::aid-chem3196>3.0.co;2-m
摘要:Piotrowski H, Hilt G, Schulz A, Mayer P, Polborn K, Severin K. Self-assembled organometallic [12]metallacrown-3 complexes. Chemistry. 2001 Aug 03;7(15):3196–208. doi: 10.1002/1521-3765(20010803)7:15<3196::aid-chem3196>3.0.co;2-m.
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