专利号:US-7956011-B2 优先权日:2005-05-04 标题:Materials and methods for the photodirected synthesis of oligonucleotide arrays 发明人:SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN 权利人:CANCER RES INST ROYAL 摘要:Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.
专利号:US-2023192731-A1 优先权日:2020-05-29 标 题 :Process for the stepwise synthesis of silahydrocarbons 发明人:AUNER NORBERT; STURM ALEXANDER G; SANTOWSKI TOBIAS; FELDER THORSTEN 权利人:MOMENTIVE PERFORMANCE MAT INC 摘要:The invention relates to a process for the stepwise synthesis of silahydrocarbons bearing up to four different organyl substituents at the silicon atom, wherein the process includes at least one step a) of producing a bifunctional hydridochlorosilane by a redistribution reaction, selective chlorination of hydridosilanes with an ether/HCl reagent, or by selective chlorination of hydridosilanes with SiCl 4 , at least one step b) of submitting a bifunctional hydridochloromonosilane to a hydrosilylation reaction, at least one step c) of hydrogenation of a chloromonosilane, and a step d) in which a silahydrocarbon compound is obtained in a hydrosilylation reaction.
专利号:US-9802953-B2 优先权日:2007-10-03 标 题 :Intermediates and methods for the synthesis of halichondrin B analogs 发明人:CHASE CHARLES E; ENDO ATSUSHI; FANG FRANCIS G; LI JING 权利人:EISAI R&D MAN CO LTD 摘要:Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
专利号:US-9745298-B2 优先权日:2015-05-06 标题:Synthesis of a compound that modulates kinases 发明人:IBRAHIM PRABHA N; JIN MASAYOSHI; MATSUURA SHINJI 权利人:PLEXXIKON INC; DAIICHI SANKYO CO LTD 摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nor a salt thereof, active on the receptor protein kinases c-Kit and/or c-Fms and/or Flt3. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
专利号:WO-2024064745-A1 优先权日:2022-09-21 标 题:Synthesis of reldesemtiv 发明人:PETERSON MATTHEW W; LU QING; MORGAN BRADLEY P; ASHCRAFT LUKE W; ANDERSEN DENISE 权利人:CYTOKINETICS INC 摘要:Provided herein is a process for the preparation of reldesemtiv and salts thereof. Also provided herein are intermediates used in this process and their preparation.
专利号:US-2016107992-A1 优先权日:2013-06-20 标 题:Intermediates useful for the preparation of saxagliptin 发明人:CASTALDI GRAZIANO; PALLANZA GIUSEPPE; GABOARDI MAURO; CASTALDI MARTA 权利人:CHEMELECTIVA S R L 摘要:Intermediates useful for the synthesis of saxagliptin and their preparationare described.
摘要:Krause, N.; Arisetti, N., Science of Synthesis Knowledge Updates, (2020) 3, 73. 摘要:Hlina, J. A., Science of Synthesis Knowledge Updates, (2021) 1, 85. 摘要:Jackowski, O.; Perez-Luna, A., Science of Synthesis Knowledge Updates, (2022) 3, 63. 摘要:Anderson, E. A.; Lim, D. S. W., Science of Synthesis Knowledge Updates, (2015) 1, 60. 摘要:Hlina, J. A., Science of Synthesis Knowledge Updates, (2021) 1, 121.