CAS: 1582-24-7; Pentafluorophenylboronic Acid

该化合物是一种含分子式C6F5B(OH)2的氟芳芳芳酸衍生物,其主要优点包括:由于五氟苯基组的电拉作用,苏津基-米亚乌拉的交叉反应具有高度的回活动性,这增强了中心的电益.这一化合物在合成氟化双子体结构方面特别有用,这种结构在制药,农用化学品和材料科学方面很有价值.氟化二子体的强烈诱导效应也改善了稳定性和储存寿命.此外,其晶体固态形式可以确保易于处理和精确地在反应中使用声学测量法.该产品通常在惰性条件下使用,以防止发生分解.

结构式图片

相似化合物

511295-00-4 179923-32-1 226396-32-3

欧盟法规

C&L通报

上下游产品

dichloro(pentafluorophenyl)borane tri-n-propyl borate bromopentafluorobenzene (pentafluorophenyl)trimethyltin 2-(pentafluorophenyl)-pyridine 2,3,4,5,6-pentafluoro-1-(2-thiophenyl)benzene

合成工艺路线路线简述

    氯五氟苯置于四羟基二硼,氯(2-二环己基膦基-2',4',6'-三异丙基-1,1'-联苯基)[2-(2'-氨基-1,1'-联苯)]钯(II),Potassium Acetate,2-二环己基磷-2,4,6-三异丙基联苯体系中,用 乙醇 用作溶剂,化学反应 2.0H,反应生成五氟苯硼酸
    参考文献:使用双硼酸的钯催化芳基硼化反应的范围
    标题:使用双硼酸的钯催化芳基硼化反应的范围
    摘要:Suzuki-Miyaura 反应已成为合成有机化学家更有用的工具之一.直到最近,还没有直接的方法来制造偶联反应中最重要的成分,即硼酸.目前制造硼酸的方法通常使用苛刻或浪费的试剂来制备硼酸衍生物,并且需要额外的步骤来提供所需的硼酸.先前报道的钯催化的直接硼酸合成的范围被揭开,其中包括广泛的合成有用的芳基亲电试剂.它利用新推出的第二代 Buchwald Xphos 预制钯催化剂和双硼酸.为了便于隔离并保留通常敏感的 Cb 键,
    Doi:10.1021/ja303181M

    专利信息


    专利号:US-11225655-B2
    优先权日:2010-04-16
    标题:Bi-functional complexes and methods for making and using such complexes
    发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
    权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
    摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

    专利号:US-8207337-B2
    优先权日:2007-01-29
    标 题:Reagent for organic synthesis reaction containing organic triol borate salt
    发明人:MIYAURA NORIO; YAMAMOTO YASUNORI
    权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
    摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

    专利号:WO-2025006693-A1
    优先权日:2023-06-30
    标 题 :Cannabidiol-like compounds and methods for the selective preparation of the same
    发明人:CHITTIBOYINA AMAR G; CHATTERJEE SHAMBA; PANDEY PANKAJ; KHAN IKHLAS A
    权利人:UNIV MISSISSIPPI
    摘要:In one aspect, the disclosure relates to new cannabidiol (CBD) analogs produced from allylic monoterpene alcohols and substituted resorcinols in the presence of aryl boronic acids, efficient and mild synthetic methods of making the new CBD analogs, and improved methods of making known CBD analogs. In one aspect, the methods produce low amounts of tetrahydrocannabinol (THC)-like compounds, low amounts of abnormal cannabidiol (abn-CBD) analogs, and higher amounts of CBD analogs, greatly simplifying purification. The methods can be tailored further to produce low amounts of CBD analogs and higher amounts abn-CBD analogs. In the disclosed methods, synthesis parameters can be varied in order to selectively produce a desired normal or abnormal regioisomer.

    专利号:EP-2107067-A1
    优先权日:2008-04-03
    标 题 :Boron catalysed peptide synthesis
    发明人:QUAEDFLIEG PETER JAN LEONARD MARIO; NUIJENS TIMO; VRIES DE JOHANNES GERARDUS; KALKEREN VAN HENRI ANTONIUS
    权利人:DSM IP ASSETS BV
    摘要:The invention relates to a method of synthesising a dipeptide, an oligopeptide or polypeptide comprising coupling a first amino acid or peptide to a second amino acid or peptide in the presence of a boron compound comprising a boron oxygen bond, which boron compound catalyses the formation of a peptidic bond, wherein one of the stereoisomers is formed in excess of the other stereoisomer or stereoisomers.

    专利号:KR-20120082477-A
    优先权日:2003-12-16
    标题:Synthesis Method for Reduction Alkylation of Indole at C-3 Position
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    合成参考文献


    摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 61.
    摘要:Hall, D. G.; Zheng, H., Science of Synthesis Knowledge Updates, (2011) 4, 90.
    摘要:Hay, M. B.; Hicks, J. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 129.
    摘要:Lloyd, C. M.; Dowell, K. F.; Brittain, W. D. G., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
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