CAS: 14328-52-0; H-D-Chg-Oh

该化合物是一种非蛋白性非氨基酸衍生物,其特点是环己基骨和箱酸功能,该化合物主要用于合成和制药研究,其硬性环己基结构可增强生物活性分子的相容稳定性,D的配置使其对设计对应选择性化合物很有价值,特别是在发展酶抑制剂或受体调制器方面.该酸组允许进一步衍生,便于融入复杂的分子结构.由于其独特的结构特征,该化合物常常被用于医药化学,以提高代谢稳定性和药物候选者的紧密性.

结构式图片

相似化合物

5664-29-9 109183-71-3 14328-51-9

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CAS号875-74-1 D-(-)-α-苯基甘氨酸 | CAS号63546-36-1 DL-N-Salicylide... | CAS号54750-25-3 Ristomycin-saeure | CAS号5664-29-9 环己基甘氨酸 | CAS号14429-43-7 R-N-乙酰基-环丙基乙酸 | CAS号5963-46-2 (R)-benzoylamin... | CAS号2935-35-5 (|S|)-(+)-α-苯甘氨酸 | CAS号59759-91-0 N-benzoyl-α-cyc... | CAS号85711-13-3 D-环己基甘氨醇 | CAS号70491-05-3 B°C-D-环己基甘氨酸

合成工艺路线路线简述

    左旋苯甘氨酸置于盐酸,氢气体系中,用 水,异丙醇 用作溶剂,化学反应 8.0H,以95.8%的收率获得d-环己基甘氨酸
    参考文献: Process For The Hydrogenation Of Aromatic Compounds[fr] Procede D'Hydrogenation De Composes Aromatiques
    标题: Process For The Hydrogenation Of Aromatic Compounds[fr] Procede D'Hydrogenation De Composes Aromatiques
    摘要:本发明关注的是芳香族或杂环芳香族化合物的氢化过程,特别是针对具有式(I)的化合物的环氢化.使用铂-铑混合催化剂,可以成功地进行芳香族氨基酸和氨基醇的环氢化.产品可以用作生物活性肽活性成分中的模拟物等.

    海关参考信息

    专利信息


    专利号:US-2023037284-A9
    优先权日:2018-11-30
    标题:Combination therapy of peptidomimetic macrocycles
    发明人:GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
    权利人:AILERON THERAPEUTICS INC
    摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

    专利号:US-11542283-B2
    优先权日:2018-05-28
    标题 :Synthesis of peptide borate ester compound and use thereof
    发明人:QIN YANRU
    权利人:JIANGSU CHIA TAI FENGHAI PHARMACEUTICAL CO LTD
    摘要:Provided are a peptide borate ester compound or a pharmaceutically acceptable salt thereof, a preparation method therefor, and pharmaceutical use thereof. The peptide borate ester compound or pharmaceutically acceptable salt thereof has a structure as shown in Formula (I), and is useful in the preparation of proteasome inhibitors to treat solid tumors and hematoma.

    专利号:US-9574189-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries
    发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
    权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
    摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

    专利号:US-2025084410-A1
    优先权日:2015-01-12
    标 题:Incorporation of unnatural nucleotides and methods thereof
    发明人:PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
    权利人:SYNTHORX INC
    摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

    专利号:US-2018371021-A1
    优先权日:2017-05-11
    标 题 :Peptidomimetic macrocycles and uses thereof
    发明人:AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
    权利人:AILERON THERAPEUTICS INC
    摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

    专利号:US-11702652-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries
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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

    合成参考文献


    摘要:Hall, M.; Faber, K.; Tasnádi, G., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 310.
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