CAS: 108342-87-6; 2,3,4,6-Tetra-O-Pivaloyl-ß-D-Galactopyranosylamine

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7284-37-9 888963-33-5 74867-91-7

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CAS号606092-33-5 N-(2,3,4,6-tetr... | CAS号108342-86-5 2,3,4,6-tetra-O... | CAS号606092-30-2 N-(2,3,4,6-tetr... | CAS号108342-85-4 β-D-半乳糖五新戊酸酯

📜β-半乳糖苷酶置于吡啶,叠氮基三甲基硅烷,四氯化锡,三苯基膦体系中,用 四氢呋喃,二氯甲烷,氯仿,水 用作溶剂,化学反应 385.0H,反应生成2,3,4,6-四-O-叔戊酰基-Beta-D-吡喃半乳糖胺
参考文献:由石胆酸合成顺铂衍生物
标题:由石胆酸合成顺铂衍生物
摘要:使用一种简单有效的方法合成了一种新的甾体-铂(II)杂化化合物.通过交叉复分解(cm)为关键步骤的收敛方法进行合成.得自石胆酸的烯烃和得自1-丝氨酸的乙烯基取代的乙二胺用作手性结构单元,它们在cm步骤中结合.该方法的最重要优点是将1-丝氨酸用作便宜的立体异构纯底物.使在侧链中具有二氨基系统的类固醇与四氯铂酸钾反应以获得目标铂(II)络合物.使用不对称strecker反应合成相似的二胺体系的尝试均未成功.
Doi:10.1016/j.Tet.2018.01.007

专利信息

专利号:WO-8800592-A1
优先权日:1986-07-18
标题:DIASTEROSELECTIVE STRECKER SYNTHESIS OF alpha-AMINOACIDS FROM GLYCOSYLAMINE DERIVATES
发明人：KUNZ HORST; SAGER WILFRIED; PFRENGE WALDEMAR; DECKER MATHIAS
权利人:CELAMERCK GMBH & CO KG
摘要:O-acyl-protected glycosylamines, in particular 2,3,4,6-tetra-O-pivaloyl-beta-D-galactopyranosylamine (1), their preparation and their use for the diastereoselective synthesis of alpha-aminoacids. With compounds such as (1), one can obtain by Strecker synthesis high yields and high diastereomer surplus. The direction of the asymmetric induction can be determined by the selection of the solvent. This type of synthesis is particularly effective when carried with Lewis acid catalysts. One obtains also high yields and high diastereoselectivity during Ugi four component synthesis facilitated by Lewis acids by using amines such as (1).

专利号:EP-0274515-A1
优先权日:1986-07-18
标题 :DIASTEROSELECTIVE STRECKER SYNTHESIS OF $g(a)-AMINOACIDS FROM GLYCOSYLAMINE DERIVATES