CAS: 104960-50-1; 2-Mercapto-6-(Thiophen-2-yl)-4-(Trifluoromethyl)Nicotinonitrile

相似化合物

330645-53-9 286430-58-8 22123-11-1

上下游产品

1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione Cyanothioacetamide 1-(2-thenoyl)-2-(1-morpholino)-3,3,3-trifluoro-1-propene 2-Acetylthiophene 2-(2-Nitro-benzylsulfanyl)-6-thiophen-2-yl-4-trifluoromethyl-nicotinonitrile N-phenyl-acetamide2-(3-cyano-6-thiophen-2-yl-4-trifluoromethyl-pyridin-2-ylsulfanyl)-N-phenyl-acetamide b]pyridine-2-carboxylic acid phenylamide3-amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide 2-acetyl-3-amino-6-(2'-thienyl)-4-trifluoromethylthieno[2,3-b]pyridine

📜2-乙酰基噻吩置于三乙烯二胺,Sodium Methylate体系中,用 四氢呋喃,甲醇,乙醇 用作溶剂,化学反应生成2-疏基-6-(2-噻吩基)-4-三氟代甲基吡啶-3-腈
参考文献:Discovery And Structure-activity Relationships Study Of Novel Thieno[2,3-B]Pyridine Analogues As Hepatitis C Virus Inhibitors
标题:Discovery And Structure-activity Relationships Study Of Novel Thieno[2,3-B]Pyridine Analogues As Hepatitis C Virus Inhibitors
摘要:Current Treatment For Hepatitis C Is Barely Satisfactory,There Is An Urgent Need To Develop Novel Agents For Combating Hepatitis C Virus Infection. This Study Discovered A New Class Of Thieno[ 2,3-B] Pyridine Derivatives As Hcv Inhibitors. First,A Hit Compound Characterized By A Thienopyridine Core Was Identified In A Cell-Based Screening Of Our Privileged Small Molecule Library. And Then,Structure Activity Relationship Study Of The Hit Compound Led To The Discovery Of Several Potent Compounds Without Obvious Cytotoxicity In Vitro (12C,Ec50 = 3.3 Mu M,Si > 30.3,12B,Ec50 = 3.5 Mu M,Si > 28.6,10L,Ec50 = 3.9 Mu M,Si > 25.6,12O,Ec50 = 4.5 Mu M,Si > 22.2,Respectively). Although The Mechanism Of Them Had Not Been Clearly Elucidated,Our Preliminary Optimization Of This Class Of Compounds Had Provided Us A Start Point To Develop New Anti-Hcv Agents. (C) 2014 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2014.01.075

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.