专利号:US-11738092-B2 优先权日:2019-12-04 标题:Methods and compositions for synthesis of therapeutic nanoparticles 发明人:WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J 权利人:DANTARI INC 摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.
专利号:US-2023355800-A1 优先权日:2019-12-04 标 题 :Methods and compositions for synthesis of therapeutic nanoparticles
专利号:AU-2020397848-A1 优先权日:2019-12-04 标 题:Methods and compositions for synthesis of therapeutic nanoparticles
专利号:EP-4069707-A2 优先权日:2019-12-04 标 题 :Methods and compositions for synthesis of therapeutic nanoparticles
专利号:WO-2021113643-A2 优先权日:2019-12-04 标题:Methods and compositions for synthesis of therapeutic nanoparticles
专利号:US-2021170049-A1 优先权日:2019-12-04 标题:Methods and compositions for synthesis of therapeutic nanoparticles
参考标题:Synthesis Of 5,7-Diarylindoles Via Suzuki-Miyaura Coupling In Water 作者:Vijayaragavan Elumalai,Jørn H. Hansen 摘要:The Synthesis Of Novel 5,7-Diaryl And Diheteroaryl Indoles Has Been Explored Via Efficient Double Suzuki-Miyaura Coupling. The Method Notably Employs A Low Catalyst Loading Of Pd(Pph3)4 (1.5 Mol%/coupling) And Water As The Reaction Solvent To Obtain 5,7-Diarylated Indoles Without Using N-Protecting Groups In Up To 91% Yield. The Approach Is Also Suitable For N-Protected And 3-Substituted Indoles And
合成参考文献
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