CAS: 10036-64-3; N-Acetyl-α-D-Glucosamine

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📜P-Nitrophenyl 2-Acetamido-4-O-(2-Acetamido-2-Deoxy-β-D-Glucopyranosyl)-2-Deoxy-β-D-Glucopyranoside置于salmonella Chitinase体系中,化学反应 3.33H,反应生成2-乙酰氨基-2-脱氧-Alpha-D-吡喃糖
参考文献:新型鼠伤寒沙门氏菌几丁质酶的表征,该酶水解几丁质,壳寡糖和n-乙酰基乳糖胺共轭物
标题:新型鼠伤寒沙门氏菌几丁质酶的表征,该酶水解几丁质,壳寡糖和n-乙酰基乳糖胺共轭物
摘要:沙门氏菌含有注释为几丁质酶的基因.然而,它们的几丁质分解活性从未得到证实.现在,我们证明了针对分配给鼠伤寒沙门氏菌sl1344中sl0018(chia)基因编码的糖苷水解酶家族18的几丁质酶的这种活性.通过pcr扩增缺乏假定的几丁质结合域的chia的c末端截短形式,克隆并在具有n末端(his)6标签的大肠杆菌bl21(de3)中表达.纯化的酶水解4-硝基苯基n,N'-二乙酰基-β-D-壳聚糖,4-硝基苯基β-D-N,ñ ',ñ "-Triacetylchitotriose和羧甲基甲壳素雷玛唑亮紫但不作用4-硝基苯基ñ-乙酰基β-D-Glucosaminide,肽聚糖或4-硝基苯基β-D-Cellobioside.酶活性的特征还在于使用1 H核磁共振直接监测产物的形成,这表明几丁质是释放n,N'-二乙酰基壳二糖的底物.水解在保留构型的情况下发生,并且该酶仅作用于壳寡糖底物的
Doi:10.1093/glycob/cwq174

专利信息

专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人：SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:WO-9423054-A1
优先权日:1993-04-05
标 题:Synthesis of tetrasaccharide
发明人：NILSSON KURT
权利人:PROCUR AB; NILSSON KURT
摘要:The present invention relates to a method for synthesis of a tetrasaccharide or a derivative thereof, which includes the initial synthesis with two different glycosidases of two disaccharides, or derivatives thereof, which after modification are used as donor and acceptor in chemical synthesis of the tetrasaccharide or its derivative.

专利号:US-2004058888-A1
优先权日:2000-01-13
标题:Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides
发明人：BORNAGHI LAURENT; DEKANY GYULA; DRINNAN NICHOLAS BARRY; PAPAGEORGIOU JOHN; WEST MICHAEL LEO
摘要:This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising α-D-Gal(1→3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of α-D-galactopyranosyl-(1→3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R 3 is methoxy or methyl; R 1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R 2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4 -chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.

专利号:WO-2024055132-A1
优先权日:2022-09-12
标 题 :Method for the synthesis of a branched copolymer of hyaluronic acid and poly(lactic-co-glycolic) acid
发明人：VILOS ORTIZ CRISTIAN ANDRÉS; ZACCONI FLAVIA CRISTINA MILAGRO; SALAZAR MUÑOZ JAVIER ALONSO
权利人:UNIV TALCA; UNIV PONTIFICIA CATOLICA CHILE; FUND CENTRO DE NANOCIENCIA Y NANOTECNOLOGIA
摘要:The present invention provides a method for the synthesis of a branched copolymer of hyaluronic acid (HA) and poly(lactic-co-glycolic acid) (PLGA), and the branched copolymer thus obtained (HA-g-PLGA). Said method comprises activating the PLGA with coupling reagents in a water miscible solvent; solubilizing the HA in a phosphate buffered saline solution; and adding the activated PLGA solution dropwise to the solution with HA to obtain the branched copolymer. The advantages of the present method are that it uses environmentally friendly conditions and allows the copolymer to be synthesized and purified in less than a week under laboratory conditions. In addition, the branched copolymer obtained does not present traces of any of the reagents used for its synthesis, so it can be used directly in the development of applications for human use.

专利号:US-5532147-A
优先权日:1991-08-06
标题:Enzymatic method for synthesis of carbohydrates
发明人：NILSSON KURT
摘要:A synthetic method in which is included at least one process, which is characterized by that a glycosidase (EC 3.2) is used to catalyse a reaction between a partially protected galactose derivative, or a partially protected glucose derivative, and a glycosyl doner, which is an oligosaccharide or a monosaccharide glycoside, is described. The process is suitable for synthesis of carbohydrate derivatives or for synthesis of partially protected carbohydrate intermediates which are suitable for further synthesis e.g. of blood group determinants A and B, or other carbohydrates.

专利号:WO-9518232-A1
优先权日:1993-12-24
标题 :Enzymatic method for synthesis of o-glycosylated amino acid or peptide or derivatives thereof
发明人：NILSSON KURT
权利人:NILSSON KURT
摘要:Present invention describes a method for synthesis of O-glycosylated amino acid or peptide or derivatives thereof, characterized by the use of a glycosyl donor which is a monosaccharide in pyranose or furanose form or which is an oligosaccharide, and by the use of an acceptor which is a hydroxyl group containing amino acid or peptide derivative which has been modified in its N-terminal α-amino group and in which the C-terminal carboxyl group is non-modified, employing an exo- or an endoglycosidase (EC 3.2) as catalyst in an equilibrium reaction and that the product is isolated from the reaction mixture or is used directly or after partial or complete isolation in a continued synthesis with chemical methods or with enzymatic methods.