CAS: 906552-18-9; (3R,5R)-7-[5-(4-Fluoro-Phenyl)-3-Isopropyl-2-Oxo-4-Phenyl-3-Phenylcarbamoyl-2,3-Dihydro-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid

该化合物是与药物阿托尔瓦斯特丹有关的化学化合物,主要用于降低胆固醇水平,这种杂质是合成阿托尔瓦斯特宁期间产生的副产品,其特点是具有循环沉积特征的乳腺结构.这种杂质在药物配方中存在,具有重要的意义,因为它们可能影响最终产品的功效和安全.典型的情况是,乳腺在各种条件下表现出稳定性等特性,但其再活性可因现有替代成分而不同.查明和量化阿托尔瓦斯坦.拉克坦杂质等杂质对于质量控制过程至关重要,确保活性药物成分符合管制标准.高性液体色谱和质谱测量等分析技术通常用于检测和分析药物制剂中的不纯度.了解这种不纯性的特点和行为是保持原状制剂完整性的关键.

英文名称(3R,5R)-7-[5-(4-Fluoro-Phenyl)-3-Isopropyl-2-Oxo-4-Phenyl-3-Phenylcarbamoyl-2,3-Dihydro-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid
中文名称阿托伐他汀杂质7
CAS编号906552-18-9
FDA UNII编号:PE665J9JLG
分子式:C33H35FN2O6分子量:574.65
产品CID: 1940150
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: IJPSBDFKAGUGAN-OMKZWDOSSA-N
IJPSBDFKAGUGAN-IKCUNAGZNA-N
计算化学: 氢键受体数7.0氢键供体数4.0可旋转键数12.0

MSDS等安全信息

危险描述CAUTION: May irritate eyes, skin
安全声明CAUT

上下游产品

阿托伐他汀 Atorvastatin 134523-00-5

合成工艺路线路线简述

📜阿托伐他汀以丙酮作为反应溶剂,化学反应 14.0H,反应生成 5-(4-Fluoro-Phenyl)-1-[2-((2R,4R)-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-yl)-Ethyl]-3-Isopropyl-2-Oxo-4-Phenyl-2,3-Dihydro-1H-Pyrrole-3-Carboxylic Acid Phenylamide,(3R,5R)-7-[3-(4-Fluoro-Phenyl)-5-Isopropyl-2-Oxo-3-Phenyl-4-Phenylcarbamoyl-2,3-Dihydro-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid,阿托伐他汀杂质7,
参考文献:Photochemical Behavior Of The Drug Atorvastatin In Water
标题:Photochemical Behavior Of The Drug Atorvastatin In Water
摘要:Atorvastatin Undergoes A Self-Sensitized Photooxygenation By Sunlight In Water. The Main Photoproducts,Isolated By Chromatographic Techniques,Have Been Identified By Spectroscopic Means. They Present A Lactam Ring Arising From An Oxidation Of Pyrrole Ring And An Alkyl/aryl Shift. A Mechanism Involving Singlet Oxygen Addition And An Epoxide Intermediate Is Suggested. (C) 2006 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2006.05.027