CAS: 866807-27-4; 3-Amino-6-Chloropyridine-2-Carboxylic Acid

相似化合物

1204400-58-7 866807-26-3 1112213-20-3

上下游产品

CAS号1073182-88-3 3-amino-6-chlor... | CAS号175358-01-7 3-氨基-6-氯吡啶甲酰胺 | CAS号866807-26-3 3-氨基-6-氯吡啶-2-羧酸甲酯

3-氨基-6-氯嘧啶-2-腈基置于盐酸,乙醇,Tin(Ll) Chloride体系中,用 水 作为反应溶剂,化学反应 21.0H,反应生成 3-氨基-6-氯吡啶-2-羧酸
参考文献:Wo2021014415A5
标题:Wo2021014415A5

专利信息

专利号:US-2023025807-A1
优先权日:2019-10-30
标题:Cd38 inhibitors
发明人：KULKARNI SANTOSH S; LAGU BHARAT; WU XINYUAN
权利人:MITOBRIDGE INC
摘要:The present invention is directed to a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Compounds of Formula (I) are CD38 inhibitors, which can be used to treat a disease or condition in a subject that benefits from an increase in NAD + or to treat a mitochondrial disorder in a subject. Such disease or condition is a muscle structure disorder, a neuronal activation disorder, a muscle fatigue disorder, a muscle mass disorder, a metabolic disease, a cancer, a vascular disease, an ocular vascular disease, a muscular eye disease, or a renal disease. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 30 to 135; examples 1 to 61; table). Such an exemplary compound is e.g. N-((1r,4r)-4-(2-methoxyethoxy) cyclohexyl)-5-(thiazol-5-yl)-1H-indole-7-carboxamide (II).