CAS: 834884-74-1; 4-(Thiophen-3-yl)Aniline
该化合物是一种有机化合物,其结构结构中既含有一种厌食类,又含有一种硫苯环;该化合物通常具有芳香胺和三环化合物的特性;在室温下,很可能是固体的,由于存在很强的分子间相互作用,如氢结合和芳香系统之间堆叠欧元,熔点相对较高;硫苯环有助于其电子特性,有可能使其在有机电子中有用,或成为合成较复杂分子的建筑块;此外,该化合物在有机溶剂中可能表现出中溶性,而其在水中的溶性可能由于硫苯酸混合物的缺水性性质而受到限制;与许多芳香胺一样,它也可能具有生物活动,这可能会引起药物研究的兴趣.应当注意到,安全性和处理预防措施,因为与所有化学物质都具有与矿群相关的毒性.
物理性质
- 熔点99-103 °C
- 沸点280 °C at 760 mmHg
- 闪点123.1 °C
- 密度1.196g/cm3
- PSA:26.02
- LogP:2.9973
- 折射率1.65
- 外观形态固体
- 储存条件2-8°C, 避光
- 产品应用该化合物用于合成反应剂:PD(I)-POLLY[4--(THIOPHE-3YL-ANILINE)-ANLINE]合成材料,采用现场聚合和复合组装方法.SCHIFF基底,2-METHOXY-6-[(4-THIOPPENE-3-CYL-苯基-PHEMIMINO)-甲基]-PHENOL,与O-VANILLIN发生凝聚反应.2-(1H-H-IMIDAZOL-1-YLE)-N-4-(THIOPEPHEN--3-TYL) 苯)-乙酰胺,使用HATU作为氨化物合剂对2-(1 H-IMIDAZOL-YM)乙酸作出反应.
MSDS等安全信息
- GHS象形图
- GHS符号GHS06;
注释: Skull and crossbones - 危险类别急性毒性 类别3(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2 - 警示词Danger(危险)
- 危险描述H301 |吞咽会中毒.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
- 危险等级6.1
- UN编号2811.0
- 危险品标志Xn
- 包装等级Ⅲ
- 安全声明26-36
- 危险类别码22-36/37/38
- WGK Germany3
欧盟法规
ECHA物质C&L通报上下游产品
CAS号1187890-57-8 N-(4-thiophen-3... | CAS号6165-68-0 2-噻吩硼酸 | CAS号540-37-4 对碘苯胺 | CAS号17763-80-3 4-硝基苯基三氟甲磺酸酯合成工艺路线路线简述
- 872-31-1 + 214360-73-3 = 834884-74-1
反应条件:1.1 Reagents: Triethylamine Catalysts: (Sp-4-2)-[1,1′-Bis[bis(1,1-Dimethylethyl)Phosphino-Kp]Ferrocene]Dichloropalladiu... Solvents: Toluene,Water; 1 H,60 °C
标题:Micellar Suzuki Cross-Coupling Between Thiophene And Aniline In Water And Under Air
作者:Yousif,Dawod; Et Al
参考文献:Organics 日期:2021 卷标:2(4) 页码:415-423]
= 834884-74-1
反应条件:1.1 Reagents: (1R,2S,2′s,4S)-1,3,3-Trimethylspiro[bicyclo[2.2.1]Heptane-2,3′-Oxaziridine],(1R,2S,2′r,4S)-1,3,3-Trimethylspiro[bicyclo[2.2.1]Heptane-2,3′-Oxaziridine] Solvents: Toluene; 2 H,-78 °C1.2 Reagents: Ammonium Chloride Solvents: Water
标题:Rapid Heteroatom Transfer To Arylmetals Utilizing Multifunctional Reagent Scaffolds
作者:Gao,Hongyin; Et Al
参考文献:Nature Chemistry 日期:2017 卷标:9(7) 页码:681-688]
6165-69-1 = 834884-74-1
反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane,Water; Rt -> 90 °C; 5 H,90 °C2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 2 H,Rt
标题:Identification Of Piperidine-3-Carboxamide Derivatives Inducing Senescence-Like Phenotype With Antimelanoma Activities
作者:Oh,Sangmi; Et Al
参考文献:Acs Medicinal Chemistry Letters 日期:2021 卷标:12(4) 页码:563-571]
886505-43-7 = 834884-74-1
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; Overnight,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized,Rt
标题:Physico-Chemical/electrochemical And Structural Insights Into Poly(3,4-Ethylenedioxythiophene) Grafted From Molecularly Engineered Multi-Walled Carbon Nanotube Surfaces
作者:Gatti,Teresa; Et Al
参考文献:Journal Of Nanoscience And Nanotechnology 日期:2018 卷标:18(2) 页码:1006-1018]
6165-69-1 = 834884-74-1
反应条件:1.1 Reagents: Triethylamine Catalysts: (Sp-4-2)-[1,1′-Bis[bis(1,1-Dimethylethyl)Phosphino-Kp]Ferrocene]Dichloropalladiu... Solvents: Water; 15 Min,Rt
标题:Micellar Suzuki Cross-Coupling Between Thiophene And Aniline In Water And Under Air
作者:Yousif,Dawod; Et Al
参考文献:Organics 日期:2021 卷标:2(4) 页码:415-423]
6165-69-1 = 834884-74-1
反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,2-Dimethoxyethane,Water; 1.5 H,Reflux
标题:Pyrrolinone Derivatives As A New Class Of P2X3 Receptor Antagonists Part 2: Discovery Of Orally Bioavailable Compounds
作者:Tobinaga,Hiroyuki; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(5) 页码:688-693]
6165-69-1 = 834884-74-1
反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane,Water; 4 H,100 °C
标题:Scaffold Hopping And Optimization Of Maleimide Based Porcupine Inhibitors
作者:Ho,Soo Yei; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2017 卷标:60(15) 页码:6678-6692]
20608-85-9 = 834884-74-1
反应条件:1.1 Reagents: Magnesium Catalysts: 1,2-Dibromoethane Solvents: Tetrahydrofuran; 5 Min,Rt1.2 Solvents: Tetrahydrofuran; Rt2.1 Reagents: (1R,2S,2′s,4S)-1,3,3-Trimethylspiro[bicyclo[2.2.1]Heptane-2,3′-Oxaziridine],(1R,2S,2′r,4S)-1,3,3-Trimethylspiro[bicyclo[2.2.1]Heptane-2,3′-Oxaziridine] Solvents: Toluene; 2 H,-78 °C2.2 Reagents: Ammonium Chloride Solvents: Water
标题:Rapid Heteroatom Transfer To Arylmetals Utilizing Multifunctional Reagent Scaffolds
作者:Gao,Hongyin; Et Al
参考文献:Nature Chemistry 日期:2017 卷标:9(7) 页码:681-688]
6165-68-0 + 540-37-4 = 834884-74-1
反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane,Water; 72 H,95 °C
标题:π-Extended And Six-Coordinate Iron(Ii) Complexes: Structures,Magnetic Properties,And The Electrochemical Synthesis Of A Conducting Iron(Ii) Metallopolymer
作者:Djukic,Brandon; Et Al
参考文献:Inorganic Chemistry 日期:2011 卷标:50(15) 页码:7334-7343]
28560-79-4 = 834884-74-1
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 2 H,Rt
标题:Identification Of Piperidine-3-Carboxamide Derivatives Inducing Senescence-Like Phenotype With Antimelanoma Activities
作者:Oh,Sangmi; Et Al
参考文献:Acs Medicinal Chemistry Letters 日期:2021 卷标:12(4) 页码:563-571]
6165-69-1 + 131818-17-2 = 834884-74-1
反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Dichlorobis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane,Water; Overnight,Rt -> 110 °C2.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; Overnight,Rt2.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized,Rt
标题:Physico-Chemical/electrochemical And Structural Insights Into Poly(3,4-Ethylenedioxythiophene) Grafted From Molecularly Engineered Multi-Walled Carbon Nanotube Surfaces
作者:Gatti,Teresa; Et Al
参考文献:Journal Of Nanoscience And Nanotechnology 日期:2018 卷标:18(2) 页码:1006-1018
📜4-硝基苯酚三氟甲基磺酸酯置于2-双环己基膦-2',6'-二甲氧基联苯,Potassium Phosphate Monohydrate,Palladium On Activated Charcoal,氢气,Palladium Diacetate体系中,用 乙醇,甲苯 作为反应溶剂,化学反应生成 4-(噻吩-3-基)苯胺
参考文献:Design And Synthesis Of Boronic Acid Inhibitors Of Endothelial Lipase
标题:Design And Synthesis Of Boronic Acid Inhibitors Of Endothelial Lipase
摘要:Endothelial Lipase (El) And Lipoprotein Lipase (Lpl) Are Homologous Lipases That Act On Plasma Lipoproteins. El Is Predominantly A Phospholipase And Appears To Be A Key Regulator Of Plasma Hdl-C. Lpl Is Mainly A Triglyceride Lipase Regulating (V)Ldl Levels. The Existing Biological Data Indicate That Inhibitors Selective For El Over Lpl Should Have Anti-Atherogenic Activity,Mainly Through Increasing Plasma Hdl-C Levels. We Report Here The Synthesis Of Alkyl,Aryl,Or Acyl-Substituted Phenylboronic Acids That Inhibit El. Many Of The Inhibitors Evaluated Proved To Be Nearly Equally Potent Against Both El And Lpl,But Several Exhibited Moderate To Good Selectivity For El. (C) 2011 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2011.12.043
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1038/nchem.2672
摘要:Gao H, Zhou Z, Kwon D, Coombs J, Jones S, Behnke NE, Ess DH, Kürti L. Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds. Nature Chemistry. 2016 Nov 28;9(7):681–8. doi: 10.1038/nchem.2672.
📝 需求与反馈
尽可能描述清楚需求与问题信息
