CAS: 77-37-2; Procyclidine

该化合物是一种以环己基和苯代用碳为特征的手性丙烯衍生物,其特点是在甲型碳上的环己基和苯代用替代物;该化合物具有作为制药和不对称催化构件的潜能,因此对合成有机化学具有兴趣;硬性环己基和芳香联苯组有助于消毒和电子调制,加强其在立体选择性反应中的效用;其二烯核心为进一步功能化提供了多功能的手架,而丙醇侧链则为衍生提供了额外的再活动性;该化合物的结构特征使其对医学化学研究和乳液结层设计具有价值,而精确的立体控制对后者至关重要.

结构式图片

MSDS等安全信息

上下游产品

1-phenyl-3-(pyrrolidin-1-yl)propan-1-one cyclohexylmagnesium bromide Pyrrinol ethyl 3-tetrahydro-1H-1-pyrrolilpropanoate(+/-)-1-ethyl-1-(3-cyclohexyl-3-hydroxy-3-phenyl-propyl)-pyrrolidinium; iodide (+/-)-1-(3-cyclohexyl-3-hydroxy-3-phenyl-propyl)-1-methyl-pyrrolidinium; iodide (S)-Pr°Cyclidine (R)-Pr°Cyclidine

合成工艺路线路线简述

    📜Alpha,Alpha-二苯基吡咯烷-1-丙醇置于溶剂黄146,铂体系中,化学反应生成 环苯咯丙醇
    参考文献:Adamson Et Al.,Journal Of The Chemical Society,1951,P. 52,58
    标题:Adamson Et Al.,Journal Of The Chemical Society,1951,P. 52,58

    海关参考信息

    专利信息


    专利号:WO-2025128098-A1
    优先权日:2023-12-13
    标 题 :Solid oral dosage forms, kits, and methods of using the same
    发明人:LI YING; LANGER ROBERT; TRAVERSO CARLO
    权利人:MASSACHUSETTS INST TECHNOLOGY; BRIGHAM & WOMENS HOSPITAL INC
    摘要:Provided herein are solid oral dosage forms, methods, and kits useful, e.g, for the extension of the residence time of active pharmaceutical agents in vivo by the synthesis of a polymer in situ in a subject. In particular, the solid oral dosage forms, methods, and kits disclosed herein are particularly useful for drugs that require more than once daily administration (e.g, drugs that have short half-lives).

    专利号:US-2009285888-A1
    优先权日:2005-05-13
    标题:Derivatives of dihydroxyphenylalanine
    发明人:SUSILO GISELA
    权利人:SUSILO GISELA
    摘要:The invention relates to derivatives of dihydroxyphenylalanine, to their synthesis and to pharmaceutical compositions containing said derivatives of dihydroxyphenylalanine. Furthermore, the invention relates to the use of said derivatives of dihydroxyphenylalanine and said pharmaceutical compositions for the treatment and prophylaxis of movement disorders, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, hemiparkinson-hemiatrophy, parkinsonian syndrome, Lewy body disease, frontotemporal dementia, Lytico-Bodig disease (parkinsonism/dementia/amyotrophic lateral sclerosis), striatonigral degeneration, Shy-Drager syndrome, sporadic olivopontocerebellar degeneration, progressive atrophy of the globus pallidus, progressive supranuclear palsy, Hallervorden-Spatz disease, Huntington's disease, X-linked dystonia-parkinsonism (Lubag), mitochondrial cytopathy with striatal necrosis, neuroacanthocytosis, restless legs syndrome, Wilson's disease.

    专利号:US-8318938-B2
    优先权日:2006-02-21
    标 题:Trans-fused chromenoisoquinolines synthesis and methods for use
    发明人:NICHOLS DAVID; WATTS VAL J
    权利人:NICHOLS DAVID; WATTS VAL J; PURDUE RESEARCH FOUNDATION
    摘要:Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these compounds as dopamine receptor binding compounds are described herein.

    专利号:US-10458995-B2
    优先权日:2016-03-25
    标 题 :Combinatorial synthesis and biomarker development
    发明人:MOOLA MURALIDHAR REDDY
    权利人:MOOLA MURALIDHAR REDDY
    摘要:Provided herein are methods, kits, and compositions for use in the diagnosis and treatment of diseases. Peptoids recognized by Alzheimers disease specific antibodies are identified.

    专利号:US-2023271983-A1
    优先权日:2020-07-29
    标题 :Functionalized isonitriles and products, preparation and uses thereof
    发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
    权利人:UNIV SANTIAGO COMPOSTELA
    摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

    专利号:US-9617230-B2
    优先权日:2014-12-22
    标题:Creatine prodrugs, compositions and methods of use thereof
    发明人:BRUBAKER WILLIAM F
    权利人:FARMINGTON PHARMA DEV
    摘要:The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Cho Y, Kim WS, Hur GH, Ha YC. Minimum effective drug concentrations of a transdermal patch system containing procyclidine and physostigmine for prophylaxis against soman poisoning in rhesus monkeys. Environ Toxicol Pharmacol. 2012 Jan;33(1):1-8. doi: 10.1016/j.etap.2011.10.002. Epub 2011 Oct 17. doi: 10.1016/j.ejphar.2013.08.024. Epub 2013 Sep 7. doi: 10.1016/j.neuro.2014.04.011. Epub 2014 May 9. Review. doi: 10.1016/j.tox.2013.08.005. Epub 2013 Aug 16. Erratum in: J Psychopharmacol. 2003 Mar;17(1):following table of contents. doi: 10.1016/j.neuro.2015.08.012. Epub 2015 Aug 28. Epub 2007 Jan 3. doi: 10.1016/j.neuro.2012.10.019. Epub 2012 Nov 16. doi: 10.1016/j.cbi.2012.10.002. Epub 2012 Oct 16. Review. Epub 2005 Oct 27. Leg Med (Tokyo). 2004 Oct;6(4):233-41.

    合成参考文献


    摘要:Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006., p. 197
    摘要:
    摘要:
    摘要:US Natl Inst Health; DailyMed. Current Medication Information for Kemadrin (Procyclidine Hydrochloride) (June 2003). Available from, as of March 5, 2009:
    摘要:American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009)
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