CAS: 60145-21-3; Pcb 103
该化合物是多氯联苯(PCB)家族的成员,其特点是其双联苯结构,有5个氯原子,在特定位置更换;该化合物在室温下无色至浅黄色固体,以其疏水性闻名,使其在水中无法溶解,但在有机溶剂中可溶解;PC 118显示高热稳定性和抗降解性,这助长了其在环境中的持久性;它已被各种工业应用,包括电气设备,热传输液和催化剂等,用作催化剂;然而,由于其毒理学特征,包括潜在的致癌效应和内分泌干扰,许多国家对其生产和使用实行严格管制或禁止;环境监测经常在土壤,沉积物和生物群中检测到PC 118,引起人们对其生物累积性和长期生态影响的关切;适当处理和处置对于减轻其环境和健康风险至关重要.
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: PQHZWWBJPCNNGI-UHFFFAOYSA-N
- 1S/C12H5Cl5/c13-6-1-2-9(15)8(3-6)12-10(16)4-7(14)5-11(12)17/h1-5H
- 计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
para-dichlorobenzene 2,4,6-trichloroaniline 1,3,5-trichloro-2-iodobenzene 2,5-dichloroiodobenzene 1,2,8-trichlorodibenzofuran 1,3,6,8-tetrachlorodibenzofuran 1,3,4,8-tetrachlorodibenzofuran 1,3,6,9-tetrachlorodibenzofuran合成工艺路线路线简述
📜1,4-二氯苯,2,4,6-三氯苯胺 反应生成 2,2',4,5',6-五氯联苯
参考文献:Erb,F. Et Al.,Bulletin De La Societe Chimique De France,1976,P. 964-968
标题:Erb,F. Et Al.,Bulletin De La Societe Chimique De France,1976,P. 964-968
海关参考信息
- 2903919090-氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2024002405-A1
优先权日:2022-06-01
标题 :Antimicrobial compounds, synthesis methods, and uses thereof
发明人：VERMA RAJNI; DONAVALLI KRISHNA MOHAN; ZAID GENE H
权利人:ANKH LIFE SCIENCES LTD
摘要:Fused tricyclic compounds and novel methods of synthesizing, using, and/or administering the same. Methods of inhibiting microbial activity and/or treating a microbial infection with fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds. The treatment of subjects suffering from a microbial infection comprises the step of administering to the subject one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds or a composition comprising one or more fused tricyclic compounds, bicyclic compounds, and other polycyclic compounds.
专利号:EP-4594306-A1
优先权日:2022-09-30
标 题 :Synthesis methods and intermediates for the production of remibrutinib
专利号:WO-2024069507-A1
优先权日:2022-09-30
标题 :Synthesis methods and intermediates for the production of remibrutinib
发明人：FIGUCCIA AUDE; Lovelle Lucie; PARMENTIER MICHAEL
权利人:NOVARTIS AG
摘要:This invention relates to novel processes for synthesizing N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide and to intermediates which are used in such processes.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1016/j.envres.2008.01.011
摘要:Tsuneta T, Loch-Caruso R, Quensen JF, Boyd SA, Hanna M, Grindatti C. Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. Environmental Research. 2008 Jun;107(2):185–93. doi: 10.1016/j.envres.2008.01.011.
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