CAS: 60-89-9; 10-((1-Methylpiperidin-3-yl)Methyl)-10H-Phenothiazine

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N-烯丙基吩噻嗪 10-Allyl-10H-Phenothiazine 20962-92-9

合成工艺路线路线简述

    📜N-烯丙基吩噻嗪置于lithium Aluminium Tetrahydride,Palladium On Activated Charcoal,氢气,Nickel(II) Acetate Tetrahydrate,Magnesium Bromide Ethyl Etherate,1,2-双(二苯基膦)乙烷体系中,用 乙腈 作为反应溶剂,化学反应 27.0H,反应生成 哌卡嗪
    参考文献:由镍电子穿梭催化实现的跨烯烃双烷基-烷基键结构
    标题:由镍电子穿梭催化实现的跨烯烃双烷基-烷基键结构
    摘要:在简单未活化烯烃的 C=c 键上选择性构建两个不同的烷基-烷基键是有机合成中持续存在的挑战.通过经典有机金属基元反应机制(氧化加成/金属转移/还原消除)进行的过渡金属催化的烯烃二碳官能化反应受到烷基金属中间体的非成键副反应性(容易的β-氢化物消除)的影响,因此强烈限制了底物烯烃和偶联剂的范围.在这里,我们证明了烷基-金属副反应性的问题可以通过电子穿梭催化方法来克服,其中金属催化剂充当电子穿梭来诱导和猝灭自由基中间体并通过自由基促进烷基-烷基键的形成.不饱和键加成.该策略应用于具有通过镍电子穿梭催化产生的两个不同烷基-烷基键的烯烃的模块化烷基化氨甲基化.机理研究支持以碳为中心的自由基物种的形成以及自由基加成过程的参与.
    DOI:10.1038/s41929-023-01015-1

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    专利信息


    专利号:US-2007287821-A1
    优先权日:2004-09-06
    标 题:Synthesis of Polynaphthalenes and Their Use
    发明人：DOETZ FLORIAN; NORD SIMON; WEISS HORST; ROSCH JOACHIM
    权利人:BASF AG
    摘要:The present invention relates to a process for preparing polynaphthalene derivatives comprising repeating units of the general formula Ia and/or Ib n n nwhere R 1 , R 2 , R 1′ , R 2′ are as defined in the description. The present invention further relates to polynaphthalene derivatives which can be prepared by the process of the invention, films comprising or consisting of at least one polynaphthalene derivative according to the invention, organic light-emitting diodes (OLEDs) comprising at least one polynaphthalene derivative according to the invention, a light-emitting layer comprising or consisting of at least one polynaphthalene derivative according to the invention, an OLED comprising the light-emitting layer of the invention, devices comprising an OLED according to the invention and the use of the polynaphthalene derivatives of the invention as emitter substances in OLEDs.

    专利号:US-2008213623-A1
    优先权日:2005-04-28
    标题:Synthesis Of Phenyl-Substituted Polyfluoroanthenes and the Use Thereof

    专利号:JP-2008512505-A
    优先权日:2004-09-06
    标题 :Synthesis of polynaphthalene and use of the polynaphthalene

    专利号:WO-2006027191-A1
    优先权日:2004-09-06
    标 题 :Synthesis of polynaphthalenes and their use

    专利号:JP-5021626-B2
    优先权日:2005-04-28
    标 题:Synthesis of phenyl-substituted polyfluoranthene and its use

    专利号:KR-20070058590-A
    优先权日:2004-09-06
    标题 :Synthesis of polynaphthalenes and their use

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    主要参考文献


    1: Brown DA, Quilliam JP. The effects of some centrally acting drugs on ganglionic transmission in the cat. Br J Pharmacol Chemother. 1964 Oct;23(2):241-56.
    2: DOUGHTY AG. Oral premedication in children: a controlled clinical trial of pecazine, trimeprazine and methylpentynol. Br J Anaesth. 1962 Feb;34:80-9.

    合成参考文献


    摘要:Farmakologiya i Toksikologiya, 24(136), 1961 []
    摘要:Arzneimittel-Forschung. Drug Research., 4(232), 1954 []
    摘要:Arzneimittel-Forschung. Drug Research., 8(489), 1958 []
    摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
    摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/Q_schafer832.pdf
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