CAS: 573-57-9; 1,4-Epoxy-1,4-Dihydronaphthalene

上下游产品

furan 1-bromo-2-(methylsulfinyl)benzene ethylmagnesium bromide o-chlorophenyl phenyl sulfoxide 2-phenylnaphthalene H-4,9-epoxido-naphtho[2,3-d][1,2,3]triazole1-phenyl-3a,4,9,9a-tetrahydro-1H-4,9-epoxido-naphtho[2,3-d][1,2,3]triazole 1-(4-(naphthalen-2-yl)phenyl)ethan-1-one

📜乙酸苯酯置于吡啶,降冰片烯,Chlorobis(Cyclooctene)-Iridium(I) Dimer,Di-μ-Chlorobis(Norbornadiene)Dirhodium(I),三(4-甲氧苯基)膦,四丁基氟化铵体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 9.25H,反应生成 1,4-二氢-1,4-环氧萘
参考文献:具有无痕,多功能缩醛导向基团的苯酚催化还原正-C-H 甲硅烷基化和二恶唑啉的合成应用
标题:具有无痕,多功能缩醛导向基团的苯酚催化还原正-C-H 甲硅烷基化和二恶唑啉的合成应用
摘要:一种新的,高选择性的键官能化策略,通过两种过渡金属催化剂的中继和无痕缩醛导向基团的使用实现,已被用于在单个容器中轻松形成 C-Si 键并伴随硅基团的官能化. 具体而言,该方法涉及廉价且容易获得的乙酸苯酯的 Ir 催化氢化硅烷化的中继,利用二取代的甲硅烷基合成子提供甲硅烷基缩醛和 Rh 催化的邻-Ch 甲硅烷基化以提供二恶唑啉.随后对硅的亲核加成去除了缩醛导向基团并直接提供未掩蔽的苯酚产物,从而在单个容器中获得硅上的有用官能团.这种用于苯酚催化邻 Ch 甲硅烷基化的无痕缩醛导向基团策略也成功应用于多取代芳烃的制备.值得注意的是,已经开发了一种新的正式 α-氯乙酰导向基团,它允许空间位阻酚的催化还原 Ch 甲硅烷基化.特别是,这种新方法允许获得其他催化途径难以获得的高度通用且分化非常好的 1,2,3-三取代芳烃.此外,所得二恶唑啉可以作为色谱稳定的卤代硅烷等价物,不仅可以去除缩醛导向基团,还可以
DOI:10.1021/jacs.6B04018

专利信息

专利号:US-9783519-B2
优先权日:2015-06-18
标 题:Palladium/silver co-catalyzed tandem reactions synthesis of phenylacetophenone derivatives by oxabenzonorbornadienes with terminal alkynes and their anti-tumor or anti-cancer activities
发明人：BIAN ZHAOXIANG; LIN CHENGYUAN; MU HUAIXUE; FAN BAOMIN; ZHOU YONGYUN; CHEN JINGCHAO; LU AIPING; CHAN ALBERT SUN-CHI
权利人:UNIV HONG KONG BAPTIST UNIV; UNIV YUNNAN MINZU
摘要:This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds. More particularly, it relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds comprising phenylacetophenone derivatives using oxabenzonorbornadienes with terminal alkynes.

专利号:US-8835658-B2
优先权日:2012-12-28
标 题:Asymmetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities
发明人：CHAN ALBERT SUN-CHI; FAN BAOMIN; WANG JUN; LIN CHENGYUAN; HUANG CHAO; YANG QINGJING; XU JIANBIN; BIAN ZHAOXIANG; LU AIPING; HU JUN
权利人:UNIV HONG KONG BAPTIST; UNIV YUNNAN NATIONALITIES
摘要:The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.

专利号:US-4154745-A
优先权日:1977-05-02
标题:Isobenzofuran route to anthracycloquinones
发明人：KENDE ANDREW S; TSAY YUH-GENG
权利人:RESEARCH CORP
摘要:There is provided a novel method of synthesizing certain tetracyclic quinones. In particular, there is provided a novel route to the synthesis of (±)-7-deoxydaunomycinone and analogs thereof which includes the provision of novel tetrahydronaphthoquinones and tetracyclic quinone intermediates. The compounds of the present invention are provided through a route comprising a Diels-Alder addition of certain isobenzofurans to certain novel tetrahydronaphthoquinones. The products of the synthetic route provided herein may be converted into compounds of known antibiotic and antineoplastic activity.

专利号:US-2016108169-A1
优先权日:2014-09-30
标 题 :Efficient synthesis of rigid ladder polymers

专利号:US-2014187801-A1
优先权日:2012-12-28
标题:Asymetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities

专利号:US-2016368890-A1
优先权日:2015-06-18
标 题:Palladium/silver co-catalyzed tandem reactions synthesis of phenylacetophenone derivatives by oxabenzonorbornadienes with terminal alkynes and their anti-tumor or anti-cancer activities