CAS: 55028-72-3; Sodium (Z)-Rel-7-((1R,2R,3R,5S)-2-((R,E)-4-(3-Chlorophenoxy)-3-Hydroxybut-1-En-1-yl)-3,5-Dihydroxycyclopentyl)Hept-5-Enoate

专利信息

专利号:US-4707554-A
优先权日:1984-12-07
标 题 :Method of obtaining derivatives of 4β-/1'-alken-1'-yl/-2ξ,5α-dαβ-4,5,6,6α.beta.
发明人：ACHMATOWICZ BARBARA; DANIEWSKI ANDRZEJ R; MARCZAK STANISLAW; PANKOWSKI JACEK; WICHA JERZY
权利人:POLSKA AKADEMIA NAUK INSTYTUT
摘要:A new method has been disclosed for obtaining derivatives of 4β-/1'-alken-1'-yl/-2ξ,5â•?-dihydroxy-3,3aβ,4,5,6,6aβ-hexahydro-2H-cyclopenta [b] furane useful in the synthesis of prostaglandins or their analogs, and a method for obtaining new sulphonyl initial compounds of the general formula 4, in which Z denotes a hydrogen atom or a protective group, Y denotes a group of the formula â•?CHOZ 1 , in which Z 1 has the meaning stated for Z, whereby protective groups Z and Z 1 may be the same or different, and Ar denotes optionally a substituted aryl group. n In the method according to the invention the new sulphonyl derivative of the general formula 4 is alkylated with an electrophilic agent comprising: carbonyl derivatives, oxiranes and halohydrins or their derivatives; the alkylation product is transformed into derivatives of 4β-/1'-alken-1'-yl/-2ξ,5α-dihydroxy-3,3aβ,4,5,6,6a.beta.-hexahydro-2H-cyclopenta[b] furane in reactions which ensure obtaining a double bond C 13 -C 14 . n New sulphonyl initial compounds of the general formula 4 are obtained from lactone of the general formula 11, in which Z has the above stated meaning and L° denotes a leaving group, which is transformed into a sulphide; the obtained lactone-sulphide is reduced to lactol, and thereafter lactol-sulphide is oxidized to te sulphonyl derivative.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.