CAS: 517-56-6; (S)-2,10-Dimethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[de,G]Quinoline-1,11-Diol
该化合物是某些植物物种,特别是Corydalis和Papaverachae家族的植物种中自然出现的一种苯丙基碱藻类,具有显著的药理特性,包括可能与肾上腺素和多巴胺基受体发生相互作用,使其成为...
- 英文名称(S)-2,10-Dimethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[de,G]Quinoline-1,11-Diol
- 中文名称紫堇块茎碱
- IUPAC名称(S)-2,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,11-diol
- 其它别名(6As)-2,10-Dimethoxy-6-Methyl-5,6,6Aα,7-Tetrahydro-4H-Dibenzo[de,G]Quinoline-1,11-Diol; (6As)-5,6,6A,7-Tetrahydro-2,10-Dimethoxy-6-Methyl-4H-Dibenzo[de,G]Quinoline-1,11-Diol; 2,10-Dimethoxy-6Aα-Aporphine-1,11-Diol; 4,5,6Aα,7-Tetrahydro-2,10-Dimethoxy-6-Methyl-6H-Dibenzo[de,G]Quinoline-1,11-Diol; (S)-Corytuberine; 1,11-Dihydroxy-2,10-Dimethoxy-6Aα-Aporphine; 2,10-Dimethoxy-6Aalpha-Aporphine-1,11-Diol; 4H-Dibenzo[de,G]Quinoline-1,11-Diol, 5,6,6A,7-Tetrahydro-2,10-Dimethoxy-6-Methyl-, (6As)-
- CAS编号517-56-6
- MFCD编号:MFCD06809887
- FDA UNII编号:4YJ94A3D8W
- 分子式:C19H21NO4分子量:327.38
- 产品CID: 1507478
- 产品分类天然产物 → 生物碱
物理性质
MSDS等安全信息
- 警示词Warning
- 危险描述H303 may be harmful by ingestion +h313 may be harmful by skin contact +h2413 may be harmful by inhalation
- 防范说明P264 wash thoroughly after treatmentp280 wear protective gloves / wear protective clothing / wear protective eye masks / wear protective masksp305 if in eyesp351 rinse carefully with water for a few minutesp338 remove contact lenses (if any) and easy to operate, continue rinsingp337 if eye irritation persistsp2393 get medical advice / care
- 安全声明H303 may be harmful by ingestion +h313 may be harmful by skin contact +h2413 may be harmful by inhalation
上下游产品
CAS号475-67-2 异紫堇定 | CAS号485-19-8 牛心果鹼 | CAS号4277-43-4 碘化木兰花碱 | CAS号36284-37-4 is°Corydine | CAS号476-69-7 紫菫定酚合成工艺路线路线简述
📜异紫堇定碱置于水,氢溴酸体系中,化学反应生成 紫堇块茎碱
参考文献:Antinociceptive Effects Of The Extracts Of Xylopia Parviflora Bark And Its Alkaloidal Components In Experimental Animals
标题:Antinociceptive Effects Of The Extracts Of Xylopia Parviflora Bark And Its Alkaloidal Components In Experimental Animals
摘要:在本研究中,我们尝试通过醋酸诱导的小鼠扭动试验,热板试验和福尔马林试验来阐明小叶木豆树皮的镇痛活性.甲醇提取物(100和200毫克/千克,腹腔注射)对醋酸诱导的扭动次数具有抑制作用,从而显示出镇痛效果.三种生物碱成分在三种动物模型中表现出显著的镇痛效果;氯仿可溶部分(包括二级和三级生物碱)表现出最强效果.这一结果支持其在民间医学中作为镇痛剂的使用.我们测试了这些部分的主要生物碱的镇痛效果,以阐明活性成分.
DOI:10.1007/s11418-009-0356-2
海关参考信息
- 2902600000-乙苯
2905110000-甲醇
2907210001-间苯二酚
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:EP-3137618-A1
优先权日:2014-04-29
标 题 :Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds
专利号:US-2017058305-A1
优先权日:2014-04-29
标 题:Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds
专利号:US-2021198706-A1
优先权日:2014-04-29
标题 :Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds
专利号:WO-2015164960-A1
优先权日:2014-04-29
标 题:Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds
专利号:US-11613770-B2
优先权日:2013-12-04
标题:Compositions and methods for making (R)-reticuline and precursors thereof
发明人：FACCHINI PETER JAMES; FARROW SCOTT CAMERON; BEAUDOIN GUILLAUME ARTHUR WELCH
权利人:ANTHEIA INC
摘要:Methods that may be used for the manufacture of the chemical compound (R)-Reticuline and synthesis precursors thereof. Compositions useful for the synthesis (R)-Reticuline and synthesis precursors are also provided.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Zetler G. Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, corytuberine, boldine and glaucine. Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:255-81. 184(1):20-8. doi: 10.1016/j.molbiopara.2012.04.002. Epub 2012 Apr 15. 71(8):1365-70. doi: 10.1021/np8001282. Epub 2008 Aug 8. 284(36):24425-31. doi: 10.1074/jbc.M109.011320. Epub 2009 Jun 26.
5: Marques JV, Dalisay DS, Yang H, Lee C, Davin LB, Lewis NG. A multi-omics strategy resolves the elusive nature of alkaloids in Podophyllum species. Mol Biosyst. 2014 Nov;10(11):2838-49. doi: 10.1039/c4mb00403e. 580(2):697-702. doi: 10.1016/j.febslet.2005.12.085. Epub 2006 Jan 6. 586(13):1749-53. doi: 10.1016/j.febslet.2012.05.021. Epub 2012 May 26.
8: He SM, Song WL, Cong K, Wang X, Dong Y, Cai J, Zhang JJ, Zhang GH, Yang JL, Yang SC, Fan W. Identification of candidate genes involved in isoquinoline alkaloids biosynthesis in Dactylicapnos scandens by transcriptome analysis. Sci Rep. 2017 Aug 22;7(1):9119. doi: 10.1038/s41598-017-08672-w.
合成参考文献
参考文献:10.1135/cccc19881845
摘要:Táborská E, Dostál J, Bochořáková H, Věžník F. Alkaloids of Papaver argemone L. and Papaver pavoninum FISCH. et MEY. From the Argemonorhoeades FEDDE section. Collect. Czech. Chem. Commun. 1988;53(8):1845–50. doi: 10.1135/cccc19881845.
参考文献:10.1016/s0367-326x(99)00045-3
摘要:Ma WG, Fukushi Y, Tahara S. Fungitoxic alkaloids from Hokkaido Corydalis species. Fitoterapia. 1999 Jun;70(3):258–65. doi: 10.1016/s0367-326x(99)00045-3.
参考文献:10.1135/cccc19961815
摘要:Slavík J, Slavíková L. Alkaloids of Meconopsis cambrica (L.) VIG. and M. robusta HOOK. f. et THOMS. Collect. Czech. Chem. Commun. 1996;61(12):1815–22. doi: 10.1135/cccc19961815.
参考文献:10.1002/jccs.199200031
摘要:Lee S, Yang H. Isoquinoline Alkaloids from Neolitsea Konishii. J Chinese Chemical Soc. 1992 Apr;39(2):189–94. doi: 10.1002/jccs.199200031.
参考文献:10.3987/com-97-7756
摘要:Simánek V, Táborská E, Bochoráková H, Sousek J, Sedmera P, Simánek V. Fumaflorine, a New 1-Benzylisoquinoline Alkaloid from Fumaria densiflora. HETEROCYCLES. 1997;45(4):817. doi: 10.3987/com-97-7756.
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