CAS: 513-48-4; 2-Iodobutane

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CAS号78-92-2 仲丁醇 | CAS号106-97-8 丁烷 | CAS号78-86-4 2-氯丁烷 | CAS号1825-66-7 Trimethyl(1-met... | CAS号106-98-9 正丁烯 | CAS号66194-68-1 Methanesulfonic... | CAS号2348-55-2 s-butyl radical | CAS号14898-79-4 (R)-(-)-仲丁醇 | CAS号590-18-1 顺-2-丁烯 | CAS号107-01-7 2-丁烯 | CAS号10574-17-1 butan-2-yloxybenzene | CAS号583-48-2 3,4-二甲基己烷 | CAS号661-69-8 六甲基二锡 | CAS号15095-79-1 butan-2-yl(trim... | CAS号513-53-1 2-丁硫醇 | CAS号22921-59-1 CHEMBRDG-BB 6539813 | CAS号106-98-9 正丁烯 | CAS号590-18-1 顺-2-丁烯 | CAS号624-64-6 反-2-丁烯 | CAS号624-24-8 戊酸甲酯

📜(1R)-1-甲基丙基甲烷磺酸酯置于sodium Iodide体系中,用 丙酮 作为反应溶剂,化学反应 19.0H,反应生成 2-碘丁烷
参考文献:莫舍尔硫酸盐:用于确定s N 2底物对映体过量的试剂
标题:莫舍尔硫酸盐:用于确定s N 2底物对映体过量的试剂
摘要:Mosher的硫代酸2-甲氧基-2-三氟甲基苯基乙酸硫代酸的外消旋和(S)-对映异构体与质子海绵[1,8-双(二甲基氨基)萘]形成空气稳定的盐.这些盐是强大的亲核试剂反应,该干净(s ñ在cdcl 2反转)3与光学活性烷基卤化物范围从非活化的烷基溴化物和碘化物,以苄基溴化物反应性.硫酯产物的非对映体过量(de)表示起始烷基卤化物的对映体过量(ee).
DOI:10.1016/j.Tetlet.2010.03.041

专利信息

专利号:WO-2015183067-A1
优先权日:2014-05-30
标题 :Synthesis of analogues of y-amino acids and resulting products
发明人：FERNÃ?NDEZ ZERTUCHE MARIO; TOVAR GUDIÑO ERIKA; TRUJILLO FERRARA JOSÉ GUADALUPE; GUEVARA SALAZAR JUAN ALBERTO
权利人:UNIV AUTÓNOMA DEL ESTADO DE MORELOS
摘要:The invention relates to a compound of formula (see formula), suitable for use as drugs in the treatment of chronic neurodegenerative disorders of the Huntington's disease, Parkinson's disease and epilepsy type, inter alia . The invention relates to novel methods for the synthesis of said analogues and the pharmaceutically acceptable solvates and salts thereof.

专利号:US-2014336369-A1
优先权日:2011-06-28
标题:Process for preparing heparinoids and intermediates useful in the synthesis thereof
发明人：KOVI RAVISHANKER; NAIK ASHISH; PATEL BRIJESH; MADALA MURALIKRISHNA
权利人:APICORE US LLC
摘要:Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.

专利号:US-9346851-B2
优先权日:2008-02-22
标 题 :Chemical modification of proteins
发明人：BERNARDES GONCALO; CHALKER JUSTIN; DAVIS BENJAMIN
权利人:BERNARDES GONCALO; CHALKER JUSTIN; DAVIS BENJAMIN; RP SCHERER TECHNOLOGIES LLC
摘要:The invention relates to methods for selectively converting a cysteine residue in a peptide or protein to the dehydroalanine (Dha) residue. The method also works on selenocysteine and substituted cysteine and selenocysteine residues, resulting in the Dha residue which may be converted to any natural or unnatural amino acid residue desired without the alteration of the remainder of the peptide or protein. The invention also allows ligation of a desired peptide at any point rather than at a point where there should be a naturally occurring cysteine, thereby allowing native chemical ligation to be used in the synthesis of peptides that do not contain cysteine. The methodology allows for the synthesis of very large peptides.

专利号:US-2009143426-A1
优先权日:2007-12-04
标 题:Synthesis of 1,3,6-trisubstituted-2-carboxyquinol-4-ones as selective ET A antagonists and their use as medicaments
发明人：STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
权利人:STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
摘要:The invention discloses the composition and preparation of various 1,3,6-trisubstituted-2-carboxy-quinol-4-ones of the formula 1 where R is H, alkyl, haloalkyl or hydroxyalkyl, R′ is alkyl, nitro, halogen or NR 2 ′″ where R′″ is alkyl or cycloalkyl, and R″ is H or alkyl. The composition of the invented compounds as methods of antagonizing the action of endothelin-1 to treat cardiovascular, pulmonary diseases and obstetric disorders and preterm labor and preeclampsia in mammals is disclosed.

专利号:US-8067616-B2
优先权日:2006-04-06
标 题 :Total synthesis of salinosporamide A and analogs thereof
发明人：LING TAOTAO; MACHERLA VENKATA RAMI REDDY; POTTS BARBARA CHRISTINE; MANAM RAMA RAO; MCARTHUR KATHERINE A
权利人:LING TAOTAO; MACHERLA VENKATA RAMI REDDY; POTTS BARBARA CHRISTINE; MANAM RAMA RAO; MCARTHUR KATHERINE A; NEREUS PHARMACEUTICALS INC
摘要:The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs from a compound of formula (V).

专利号:WO-2009145624-A1
优先权日:2008-05-30
标题:Use of activated carbon dioxide in the oxidation of compounds having a hydroxy group
发明人：DE JONG BOUWE; MALMSTROEM MAGNUS KRISTIAN
权利人:INOVIAKEM B V; DE JONG BOUWE; MALMSTROEM MAGNUS KRISTIAN
摘要:The invention pertains to a process for the oxidation of a compound having a hydroxy group, said process comprising the steps of: (a) oxidising said compound having a hydroxy group; (b) reducing carbon dioxide at a cathode; wherein steps (a) and(b) are effected in the presence of an ionic liquid. The course of the reaction may be directed, such as stimulating or suppressing oligomerization, resulting in the controlled synthesis of a wide variety of products, e.g. dialkyl carbonates, and lactic acid and/or lactide (which may be further converted to acrylic acid).