CAS: 50976-35-7; Sodium 6-Aminonaphthalene-1,3-Disulfonate

该化合物是一种水溶性芳香磺酸化合物,其特点是有氨基和磺酸盐功能组群,其主要优点包括高热稳定性和水溶液的溶性极佳,适合染料,荧光探针和化学中间体的应用;全氟辛烷磺酸组的存在增强了其与极溶剂的兼容性,而氨基氨基化合物组则为进一步功能化提供了再活动.该化合物由于结构坚固和可预测的再活动,经常用于合成异族染料和作为有机化学的建筑块.其酸性和基本条件的稳定性进一步扩大了其工业工艺的用途.

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    专利信息


    专利号:US-10870649-B2
    优先权日:2017-04-13
    标题:Synthesis of NIR fluorescent probe
    发明人:LATTUADA LUCIANO; BUONSANTI FEDERICA; CRIVELLIN FEDERICO; FERRETTI FULVIO; MAISANO FEDERICO; ORIO LAURA; PIZZUTO LORENA
    权利人:BRACCO IMAGING SPA
    摘要:The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.

    专利号:US-2020055855-A1
    优先权日:2017-04-13
    标题 :Improved synthesis of nir fluorescent probe

    专利号:CN-110461843-B
    优先权日:2017-04-13
    标题:Improved synthesis of NIR fluorescent probes

    专利号:EP-3609892-B1
    优先权日:2017-04-13
    标 题:Improved synthesis of nir fluorescent probe

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    合成参考文献


    参考文献:10.1007/s10870-005-9063-3
    摘要:Downer SM, Squattrito PJ, Bestaoui N, Clearfield A. Structures of transition and alkaline earth metal salts of 5-aminonaphthalene-2-sulfonate and 6-aminonaphthalene-1, 3-disulfonate: Some unusual coordination behaviors. Journal of Chemical Crystallography. 2006 Jun 07;36(8):487–501. doi: 10.1007/s10870-005-9063-3.
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