CAS: 499195-47-0; 4-(3-Bromophenyl)-2-Chloropyrimidine
该化合物是一种卤化的火米丁衍生物,在制药和农用化学研究方面有很大的效用,该化合物的特点是4位置的溴联苯组和2位置的环的氯替代体,为进一步的功能化提供了独特的反应性;其结构特性使它成为铃木-米亚鲁的交叉反应和其他催化变体中的宝贵中间体;溴和氯的存在增强了其在选择性替代反应中的多用途性,使得能够合成复杂的环环状框架;该化合物在药用化学中对于发展动脉抑制剂和其他生物活性分子特别有用;高纯度和稳定性确保合成应用的可靠性能.
- 英文名称4-(3-Bromophenyl)-2-Chloropyrimidine
- 中文名称4-(3-溴苯基)-2-氯嘧啶
- IUPAC名称4-(3-bromophenyl)-2-chloropyrimidine
- 其它别名Pyrimidine, 4-(3-Bromophenyl)-2-Chloro; 4-(3-Bromophenyl)-2-Chloropyrimidine
- CAS编号499195-47-0
- MFCD编号:MFCD11520124
- EINECS号:850-260-1
- 分子式:C10H6BrClN2分子量:269.53
- 产品CID: 1485794
- 产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物
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欧盟法规
C&L通报合成工艺路线路线简述
📜3'-溴苯乙酮置于1,10-菲罗啉,Tetrakis(Acetonitrile)Copper(I)Tetrafluoroborate,Fac-Tris(2-(4'-Tert-Butyl)Phenylpyridine)Iridium(Iii),盐酸羟胺,Sodium Acetate,三乙胺,三氯氧磷体系中,用 甲醇,二氯甲烷,氯苯 作为反应溶剂,化学反应 25.67H,反应生成 4-(3-溴苯基)-2-氯嘧啶
参考文献:Access To Cyanoimines Enabled By Dual Photoredox/copper-Catalyzed Cyanation Of O-Acyl Oximes
标题:Access To Cyanoimines Enabled By Dual Photoredox/copper-Catalyzed Cyanation Of O-Acyl Oximes
摘要:An Efficient Strategy For The Synthesis Of Pharmaceutically Important And Synthetically Useful Cyanoimines,As Well As Cyanamides,Has Been Described. This Strategy Is Enabled By Dual Photoredox/copper-Catalyzed Cyanation Of O-Acyl Oximes Or O-Acyl Hydroxamides. This State Of The Art Protocol For Cyanoimines And Cyanamides Features Readily Available Starting Materials,Mild Reaction Conditions,Good Functional Group Tolerance,And Operational Simplicity. The Resultant Cyanoimines Can Be Transformed Into Structurally Diverse And Functionally Important N-Containing Heterocycles.
DOI:10.1021/acs.Orglett.0C02659
