CAS: 492-86-4; 4-Chloromandelic Acid

上下游产品

2,2-dibromo-1-(4-chlorophenyl)ethanone 4-chloromandelonitrile dichloroacethyl chloride chlorobenzene methyl 4-chloromandelate ethyl 2-(4-chlorophenyl)-2-hydroxyacetate chloro-(4-chloro-phenyl)-acetic acid methyl ester ethoxy-(4-chloro-phenyl)-acetic acid ethyl ester

2-(4-Chlorophenyl)-N,2-Dihydroxyacetamide置于sodium Hydroxide体系中,用 乙腈 作为反应溶剂,化学反应 3.0H,以86%的收率获得产物对氯扁桃酸
参考文献:异羟肟酸的简单合成及其转化为α-羟基和α-氨基酸
标题:异羟肟酸的简单合成及其转化为α-羟基和α-氨基酸
摘要:在羟基胺衍生物的存在下,Libr或li 2 Nibr 4对宝石-二氰基环氧化合物的亲核开环会导致新的α-卤代异羟肟酸.这些化合物已经以非常好的产率用于合成α-官能化的异羟肟酸,α-羟基和α-氨基酸.
DOI:10.1016/s0040-4039(00)00228-8

专利信息

专利号:US-5399721-A
优先权日:1990-01-12
标题:Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
发明人：HOPPER ALLEN T; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. the invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.

专利号:WO-2012142983-A1
优先权日:2011-04-19
标 题 :Optically active salts of (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahydro-3ah- cyclopenta-[d] [1,3]dioxol-4-ol and a method of their preparation
发明人：LUSTIG PETR; HEJTMANKOVA LUDMILA
权利人:ZENTIVA KS; LUSTIG PETR; HEJTMANKOVA LUDMILA
摘要:Diastereomeric salts of the compound of formula I with D-(-)-mandelic and R-(-)-3- chloromandelic acid, a method of for the preparation thereof and their use in the synthesis of the drug ticagrelor.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-8796488-B2
优先权日:2010-01-29
标 题:Process for the preparation of lacosamide
发明人：BOLOGNA ALBERTO; CASTOLDI PATRIZIA; VERGANI DOMENICO; BERTOLINI GIORGIO
权利人:BOLOGNA ALBERTO; CASTOLDI PATRIZIA; VERGANI DOMENICO; BERTOLINI GIORGIO; EUTICALS SPA
摘要:A novel process for the synthesis of Lacosamide using D,L-serine as starting material is described, where the methylation reaction of hydroxyl is carried out using an inexpensive base such as NaOH and an inexpensive alkylating agent, non-toxic and non-carcinogenic, such as methyl p-toluenesulfonate; the R enantiomer is isolated from the racemic mixture of Lacosamide after selective hydrolysis of the acetamide, salification of the racemic mixture with a chiral acid (HX*) in an organic solvent, resolution of the diastereoisomeric mixture, preferably by precipitation of the R enantiomer, and subsequent acetylation of the optically pure intermediate.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-12378242-B2
优先权日:2018-06-29
标题 :Inhibiting CREB binding protein (CBP)
发明人：SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST Angela; DOWNING JENNIFER R; ERICSSON ANNA
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.