CAS: 460-25-3; 1,3-Dibromo-1,1-Difluoropropane

上下游产品

CAS号54509-73-8 ethene | CAS号75-61-6 二溴二氟烷 | CAS号430-85-3 1,1-二溴二氟乙烯 | CAS号460-32-2 3-溴-1,1,1-三氟丙烷 | CAS号420-90-6 3-溴-3,3-二氟丙烯 | CAS号60917-29-5 3-溴-1,1-二氟丙烯 | CAS号64545-26-2 1,1-difluoropro...

📜乙烯,二溴二氟甲烷置于过氧化苯甲酰体系中,化学反应 18.0H,以78%的收率获得产物1,3-二溴-1,1-二氟丙烷
参考文献:Gem-(二氟烯丙基)锂:锂-卤素交换制备及其在有机硅和有机合成中的应用
标题:Gem-(二氟烯丙基)锂:锂-卤素交换制备及其在有机硅和有机合成中的应用
摘要:摘要 : Gem-二氟烯丙基锂可以通过正丁基锂和 Ch2=chcf2Br置于-95 摄氏度下使用原位程序进行溴化锂交换来反应生成.当此 Li(Cf2Chch2) 制备在氯硅烷,醛,酮和酯的存在下进行时,分别为 R3Sicf2Ch=ch2,Rch(Oh)Cf2Ch=ch2,Rr'C-(Oh)Cf2Ch=ch 类型的产物,形成,通常产量非常好.除了不对称取代的烯丙基锂试剂的 C=0 之外,还讨论了决定区域选择性的因素.(作者)
DOI:10.1021/ja00352A019

专利信息

专利号:US-10414903-B2
优先权日:2016-11-11
标题 :Methods for synthesis of end-functionalized polyolefins
发明人：GUIRONNET DAMIEN S; HYATT MICHAEL G; WALSH DYLAN J
权利人:UNIV ILLINOIS
摘要:A strategy for the synthesis of semi-telechelic polyethylene through the palladium diimine-catalyzed chain transfer polymerization of ethylene using various silanes as chain transfer agents is reported. Polymer molecular weight and end-group chemical structure can be tuned by varying the chain transfer agent as well as its concentration. NMR spectroscopy confirms that the silicon of the chain transfer agent is incorporated into the polymer. The stability of the catalyst toward polar monomer enables the chain transfer polymerization of semi-telechelic poly(ethylene-methyl acrylate) copolymers.

专利号:US-10266503-B1
优先权日:2016-05-24
标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins
发明人：WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN
权利人:UNIV ILLINOIS
摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.

专利号:WO-2017214534-A1
优先权日:2016-06-10
标 题:Synthesis of the arylomycin macrocyclic core
发明人：ROMESBERG FLOYD E; BARAN PHIL; PETERS DAVID
权利人:SCRIPPS RESEARCH INST
摘要:The invention provides a copper-mediated process for making compounds according to Formula (I): that are the macrocyclic scaffolds of the arylomycin class of biologically active compounds, where R 1 , R 2 , R 3 , R A1 , R A2 , R A3 , B, G 1 , G 2 , PG, n2, and n3 are defined in the specification.

专利号:US-2023159678-A1
优先权日:2020-06-19
标题:Methods of polymerization with aromatic thiol initiators
发明人：BOWMAN CHRISTOPHER N; LOVE DILLON
权利人:UNIV COLORADO REGENTS
摘要:Provided herein are methods of using aryl thiols as photoinitiators. The thiol compounds are useful as oxygen insen-sitive photoinitiators for applications such as bulk polymerizations and for specialty polymer synthesis by preparing aromatic thiol functionalized macroinitiators.

专利号:WO-2011050245-A1
优先权日:2009-10-23
标 题:Bicyclic heteroaryls as kinase inhibitors
发明人：FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
权利人:FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
摘要:The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

专利号:US-2016297851-A1
优先权日:2012-03-14
标题:Broad spectrum antibiotic arylomycin analogs
发明人：ROMESBERG FLOYD E; SMITH PETER A; ROBERTS TUCKER C
权利人:ROMESBERG FLOYD E; SMITH PETER A; ROBERTS TUCKER C
摘要:Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided.